Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | PIM1 | P11309 | 1/20 | 0.47 |
| ▸ | P4HB | P07237 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MPO | P05164 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10490976 | 0.79 | MEN1 (0.54) | MEN1KMT2AEGFRPIM1P4HB | |
| SCHEMBL27897675 | 0.75 | IDO1 (0.46) | MAPTCA1CA2CYP2D6ALDH1A1 | |
| SCHEMBL8427333 | 0.70 | CES2 (0.36) | — | |
| SCHEMBL28662503 | 0.70 | ALDH1A1 (0.54) | MEN1KMT2AMAPTCYP2D6KDM4E | |
| SCHEMBL10490935 | 0.69 | HDAC4 (0.46) | MEN1KMT2AEGFRPIM1MAPT | |
| SCHEMBL9178368 | 0.68 | ALDH1A1 (0.52) | KMT2AP4HBMAPTALDH1A1LMNA | |
| SCHEMBL2673236 | 0.68 | MAPT (0.50) | MAPTTP53CYP2D6ALDH1A1LMNA | |
| SCHEMBL8062515 | 0.68 | P4HB (0.41) | P4HB | |
| SCHEMBL8382011 | 0.67 | MEN1 (0.84) | MEN1KMT2AEGFRPIM1P4HB | |
| SCHEMBL8559808 | 0.67 | ALDH1A1 (0.52) | MEN1KMT2AMAPTTSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5844004-A | 10-substituted 1,8-dihydroxy-9 (10H) anthracenone pharmaceuticals | TEVA PHARMACEUTICAL INDUSTRIES, LTD. (IL) | 1998-12-01 | — | — | US | disclosed |