Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNK3 | O14649 | 1/20 | 0.55 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 5/20 | 0.50 |
| ▸ | PPARG | P37231 | 1/20 | 0.49 |
| ▸ | PPARA | Q07869 | 1/20 | 0.49 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | GRM5 | P41594 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | SMO | Q99835 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8570812 | 0.87 | GRM4 (0.54) | KCNK3KCNK9KMT2AKDM4EMEN1 | |
| SCHEMBL8574070 | 0.84 | ALDH1A1 (0.51) | KMT2AKDM4ELMNAMEN1POLB | |
| SCHEMBL8570504 | 0.80 | HTR6 (0.52) | KMT2AKDM4ELMNAMEN1SMN1; SMN2 | |
| SCHEMBL8809240 | 0.80 | GAA (0.59) | LMNASMN1; SMN2RAB9AALDH1A1NPC1 | |
| SCHEMBL7050973 | 0.79 | KCNK9 (0.67) | KCNK3KCNK9KMT2AKDM4ELMNA | |
| SCHEMBL8569681 | 0.78 | HTR2A (0.56) | KMT2AKDM4EMEN1NR1H4POLB | |
| SCHEMBL8569833 | 0.76 | HSD11B1 (0.48) | KMT2AKDM4ELMNAMEN1PPARG | |
| SCHEMBL8569591 | 0.76 | HDAC8 (0.67) | KMT2ALMNASMN1; SMN2RAB9AALDH1A1 | |
| SCHEMBL5492048 | 0.76 | RAB9A (0.75) | KCNK3KCNK9KMT2AKDM4EMEN1 | |
| SCHEMBL21357031 | 0.75 | NPC1 (0.74) | KMT2AKDM4ELMNAMEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5739336-A | SELECTIVE 5-HYDROXYTRYPTAMINE-2C RECEPTOR ANTAGONISTS | SYNTEX (U.S.A.) INC. (US) | 1998-04-14 | — | — | US | disclosed |
| WO-1997000872-A1 | 1,3,8-TRIAZA- AND 3,8-DIAZA-1-OXASPIRO(4,5)DECANE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 1997-01-09 | — | — | WO | disclosed |