Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.56 |
| ▸ | HTR2C | P28335 | 2/20 | 0.56 |
| ▸ | HTR2B | P41595 | 2/20 | 0.56 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.47 |
| ▸ | LTB4R | Q15722 | 2/20 | 0.44 |
| ▸ | ACLY | P53396 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | PDE4A | P27815 | 2/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8574408 | 0.86 | HTR2A (0.55) | HTR2AHTR2CHTR2BNR1H4HDAC8 | |
| SCHEMBL8569833 | 0.82 | HSD11B1 (0.48) | HTR2AHTR2CHTR2BHDAC8HDAC1 | |
| SCHEMBL8569591 | 0.82 | HDAC8 (0.67) | HDAC8HDAC1KMT2AALDH1A1 | |
| SCHEMBL8569807 | 0.81 | KMT2A (0.53) | HTR2AHTR2CHTR2BHDAC8MEN1 | |
| SCHEMBL8571105 | 0.81 | HTR2A (0.55) | HTR2AHTR2CHTR2BMEN1KMT2A | |
| SCHEMBL14241382 | 0.80 | NR1H4 (0.54) | HTR2AHTR2CHTR2BNR1H4LTB4R | |
| SCHEMBL8572525 | 0.80 | ALDH1A1 (0.56) | HDAC8HDAC1MEN1KMT2APOLB | |
| SCHEMBL7391033 | 0.79 | HPGDS (0.57) | HTR2AHTR2CHTR2BNR1H4LTB4R | |
| SCHEMBL8575779 | 0.79 | HSD11B1 (0.46) | HTR2AHTR2CHTR2BHDAC8HDAC1 | |
| SCHEMBL8567801 | 0.78 | KCNK3 (0.55) | NR1H4MEN1KMT2APOLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5739336-A | SELECTIVE 5-HYDROXYTRYPTAMINE-2C RECEPTOR ANTAGONISTS | SYNTEX (U.S.A.) INC. (US) | 1998-04-14 | — | — | US | disclosed |
| WO-1997000872-A1 | 1,3,8-TRIAZA- AND 3,8-DIAZA-1-OXASPIRO(4,5)DECANE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 1997-01-09 | — | — | WO | disclosed |