Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | PRKCI | P41743 | 2/20 | 0.38 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | PLK1 | P53350 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27595047 | 0.81 | KDM4E (0.39) | KDM4EALDH1A1MAPTP2RX7GAA | |
| SCHEMBL3461907 | 0.81 | P2RX7 (0.55) | KDM4EALDH1A1MAPTP2RX7GAA | |
| SCHEMBL13544819 | 0.80 | ALDH1A1 (0.41) | KDM4EALDH1A1MAPTPRKCIYTHDC1 | |
| SCHEMBL164943 | 0.78 | YTHDC1 (0.37) | KDM4EALDH1A1MAPTPRKCIYTHDC1 | |
| SCHEMBL13544546 | 0.78 | KDM4E (0.56) | KDM4EALDH1A1MAPTYTHDC1KMT2A | |
| SCHEMBL28052540 | 0.78 | YTHDC1 (0.37) | KDM4EALDH1A1MAPTPRKCIYTHDC1 | |
| SCHEMBL15995000 | 0.78 | P2RX7 (0.40) | KDM4EALDH1A1MAPTP2RX7PRKCI | |
| SCHEMBL12497387 | 0.77 | SCD (0.40) | KDM4EALDH1A1MAPTPRKCIYTHDC1 | |
| SCHEMBL11877003 | 0.77 | MAPT (0.39) | KDM4EALDH1A1MAPTPRKCIYTHDC1 | |
| SCHEMBL2593442 | 0.77 | CASP1 (0.38) | KDM4EALDH1A1MAPTPRKCIYTHDC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5846990-A | Substituted biphenyl isoxazole sulfonamides | BRISTOL-MYERS SQUIBB CO. (US) | 1998-12-08 | — | — | US | claimed |
| US-11780827-B2 | Substituted 3-phenoxyazetidin-1-yl-pyrazines | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2023-10-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11780827-B2 | Substituted 3-phenoxyazetidin-1-yl-pyrazines | GPR52, GPR88, GPR65 | KDM4E 2808/4885ALDH1A1 1895/4885MAPT 2314/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.