SCHEMBL8570267

SCHEMBL8570267

COc1ccc(Cn2c(=O)cc(C(F)(F)F)n(C)c2=O)cc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.46
MAPT P10636 3/20 0.46
MEN1 O00255 2/20 0.46
KMT2A Q03164 2/20 0.46
KDM4E B2RXH2 3/20 0.44
ALOX15 P16050 1/20 0.44
CMA1 P23946 1/20 0.44
HPGD P15428 1/20 0.44
RGS4 P49798 2/20 0.43
RGS8 P57771 1/20 0.43
P2RX4 Q99571 1/20 0.43
GSK3A P49840 1/20 0.42
GSK3B P49841 1/20 0.42
USP2 O75604 1/20 0.42
PKM P14618 1/20 0.42
TSHR P16473 1/20 0.42
MAPK1 P28482 1/20 0.42
PARG Q86W56 1/20 0.42
PIK3CD O00329 1/20 0.41
GRM2 Q14416 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27174639 0.85 RGS4 (0.49) ALDH1A1MAPTMEN1KMT2AHPGD
SCHEMBL7475187 0.83 HPGD (0.62) ALDH1A1MAPTMEN1KMT2AHPGD
SCHEMBL16028734 0.80 HPGD (0.69) ALDH1A1MAPTMEN1KMT2AKDM4E
SCHEMBL8607569 0.79 CMA1 (0.35) ALDH1A1MAPTMEN1KMT2ACMA1
SCHEMBL7557543 0.77 GSK3A (0.46) ALDH1A1MAPTGSK3AGSK3BPIK3CD
SCHEMBL4847620 0.75 ALDH1A1 (0.50) ALDH1A1MAPTMEN1KMT2AKDM4E
SCHEMBL8566733 0.75 ALDH1A1 (0.57) ALDH1A1MAPTMEN1KMT2AKDM4E
SCHEMBL325735 0.75 MAPT (0.51) ALDH1A1MAPTMEN1KMT2AKDM4E
SCHEMBL4769071 0.75 ALDH1A1 (0.60) ALDH1A1MAPTMEN1KMT2AKDM4E
SCHEMBL8574205 0.74 UBE2N (0.33) ALDH1A1MAPTMEN1KMT2ACMA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110546152-B Bicyclic pesticide compounds 巴斯夫欧洲公司 2023-09-08 CN disclosed
US-11591335-B2 Bicyclic pesticidal compounds BASF SE (DE) 2023-02-28 US disclosed
US-11570992-B2 Bicyclic compounds BASF SE (DE) 2023-02-07 US disclosed
EP-3436457-B1 BICYCLIC COMPOUNDS BASF SE (DE) 2022-07-20 EP disclosed
EP-3621967-B1 BICYCLIC PESTICIDAL COMPOUNDS BASF SE (DE) 2022-01-19 EP disclosed
US-20200165255-A1 Bicyclic Pesticidal Compounds BASF SE (DE) 2020-05-28 US disclosed
EP-3621967-A1 BICYCLIC PESTICIDAL COMPOUNDS BASF SE (DE) 2020-03-18 EP disclosed
CN-110546152-A Bicyclic pesticidal compounds BASF SE 2019-12-06 CN disclosed
US-20190104738-A1 BICYCLIC COMPOUNDS BASF CHEMICALS INDIA PVT. LTD. (IN) 2019-04-11 US disclosed
EP-3436457-A1 BICYCLIC COMPOUNDS BASF SE (DE) 2019-02-06 EP disclosed
WO-2018206479-A1 BICYCLIC PESTICIDAL COMPOUNDS BASF SE (DE) 2018-11-15 WO disclosed
CN-108779121-A Dicyclic compound 巴斯夫欧洲公司 2018-11-09 CN disclosed
WO-2017167832-A1 BICYCLIC COMPOUNDS BASF SE (DE) 2017-10-05 WO disclosed
US-5780630-A 1-METHYL-6-TRIFLUOROMETHYL-2,4(1H,3H)PYRIMIDINEDIONE AS AN INTERMEDIATE FOR HERBICIDES E.G. 1-METHYL-6-TRIFLUOROMETHYL-3-(4-METHOXYPHENYLMETHYL) -2,4(1H,3H)PYRIMIDINEDIONE FMC CORPORATION (US) 1998-07-14 US disclosed
WO-1998008824-A1 AN INTERMEDIATE USEFUL IN THE SYNTHESIS OF PESTICIDAL URACILS FMC CORPORATION (US) 1998-03-05 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200165255-A1 Bicyclic Pesticidal Compounds DDT, ACHE, CYCS ALDH1A1 1139/4885MAPT 3539/4885MEN1 1250/4885
US-11591335-B2 Bicyclic pesticidal compounds DDT, ACHE, CYCS ALDH1A1 1139/4885MAPT 3539/4885MEN1 1250/4885
US-20190104738-A1 BICYCLIC COMPOUNDS CYP1B1, CYCS, CYP11B2 ALDH1A1 240/4885MAPT 1484/4885MEN1 555/4885
US-11570992-B2 Bicyclic compounds CYP1B1, CYCS, CYP11B2 ALDH1A1 240/4885MAPT 1484/4885MEN1 555/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.