Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.49 |
| ▸ | MEN1 | O00255 | 5/20 | 0.49 |
| ▸ | TOP1 | P11387 | 2/20 | 0.49 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.49 |
| ▸ | AHR | P35869 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 3/20 | 0.49 |
| ▸ | METAP2 | P50579 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | PNLIP | P16233 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8570812 | 0.74 | GRM4 (0.54) | NPC1RAB9AKMT2AMEN1PTGS2 | |
| SCHEMBL6300537 | 0.73 | RAB9A (0.75) | NPC1RAB9AKMT2AMEN1TOP1 | |
| SCHEMBL10657116 | 0.72 | THRB (0.49) | KMT2AMEN1MAPTALDH1A1POLB | |
| SCHEMBL1499710 | 0.71 | MAPT (0.70) | NPC1RAB9AKMT2AMEN1TOP1 | |
| SCHEMBL3738802 | 0.71 | PDE4B (0.68) | NPC1RAB9AKMT2AL3MBTL1MAPT | |
| SCHEMBL11380581 | 0.71 | ERCC5 (0.42) | KMT2AMEN1GAAKDM4EL3MBTL1 | |
| SCHEMBL5022887 | 0.70 | NPC1 (0.65) | NPC1RAB9AKMT2AMEN1AHR | |
| SCHEMBL7142354 | 0.70 | HDAC8 (0.68) | NPC1RAB9AKMT2AL3MBTL1MAPT | |
| SCHEMBL11386262 | 0.69 | ERCC5 (0.44) | KMT2AMEN1GAAKDM4EL3MBTL1 | |
| SCHEMBL8567801 | 0.69 | KCNK3 (0.55) | NPC1RAB9AKMT2AMEN1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5739336-A | SELECTIVE 5-HYDROXYTRYPTAMINE-2C RECEPTOR ANTAGONISTS | SYNTEX (U.S.A.) INC. (US) | 1998-04-14 | — | — | US | disclosed |