Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.33 |
| ▸ | GRM5 | P41594 | 2/20 | 0.32 |
| ▸ | OGA | O60502 | 1/20 | 0.30 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.30 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.30 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.30 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.30 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.30 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.30 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.30 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.30 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8575385 | 0.85 | CHRNA7 (0.33) | CHRNA7 | |
| SCHEMBL8573706 | 0.74 | TTR (0.41) | CHRNA7GRM5OGAKCNH2 | |
| SCHEMBL8571782 | 0.73 | CHRNB2 (0.33) | CHRNA7 | |
| SCHEMBL8574139 | 0.70 | CHRNA7 (0.50) | CHRNA7GRM5 | |
| Hydrochloric Acid SCHEMBL8578709 | 0.69 | CHRNA7 (0.49) | CHRNA7GRM5 | |
| SCHEMBL8921096 | 0.69 | ALDH1A1 (0.35) | SLC18A3CHRNA7 | |
| SCHEMBL8574500 | 0.68 | ACACB (0.39) | — | |
| SCHEMBL8705669 | 0.67 | ACACB (0.39) | GPR119 | |
| SCHEMBL8712010 | 0.67 | CYP1A1 (0.38) | SLC18A3GRM5KCNH2 | |
| SCHEMBL8920052 | 0.66 | KMT2A (0.53) | SLC18A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5731323-A | Quinuclidine derivatives as squalene synthase inhibitors | ZENECA LIMITED (GB) | 1998-03-24 | — | — | US | claimed |
| US-5731323-A | Quinuclidine derivatives as squalene synthase inhibitors | ZENECA LIMITED (GB) | 1998-03-24 | — | — | US | disclosed |