Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CRHBP | P24387 | 1/20 | 0.39 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8569681 | 0.79 | HTR2A (0.56) | HSD11B1KMT2AMEN1HDAC8HDAC1 | |
| SCHEMBL16540191 | 0.79 | KMT2A (0.50) | HSD11B1KMT2AMEN1ALDH1A1MAPK1 | |
| SCHEMBL8575784 | 0.79 | HDAC3 (0.48) | HSD11B1KMT2AMEN1HDAC8HDAC1 | |
| SCHEMBL8570504 | 0.78 | HTR6 (0.52) | HSD11B1KMT2AMEN1ALDH1A1MAPK1 | |
| SCHEMBL8569833 | 0.75 | HSD11B1 (0.48) | HSD11B1KMT2AMEN1HDAC8HDAC1 | |
| SCHEMBL31267400 | 0.74 | ABCB1 (0.50) | KMT2AMEN1ABCB1ALDH1A1MAPK1 | |
| SCHEMBL8569591 | 0.74 | HDAC8 (0.67) | KMT2AHDAC8HDAC1ALDH1A1 | |
| SCHEMBL8574314 | 0.74 | HTR2C (0.60) | KMT2AMEN1ALDH1A1HTR2AHTR2C | |
| SCHEMBL8571105 | 0.73 | HTR2A (0.55) | KMT2AMEN1ALDH1A1MAPK1HTR2A | |
| SCHEMBL8569807 | 0.73 | KMT2A (0.53) | HSD11B1KMT2AMEN1HDAC8ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5739336-A | SELECTIVE 5-HYDROXYTRYPTAMINE-2C RECEPTOR ANTAGONISTS | SYNTEX (U.S.A.) INC. (US) | 1998-04-14 | — | — | US | disclosed |
| WO-1997000872-A1 | 1,3,8-TRIAZA- AND 3,8-DIAZA-1-OXASPIRO(4,5)DECANE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 1997-01-09 | — | — | WO | disclosed |