Sugi Predict

Sugi Predict / Compounds / SCHEMBL858446

SCHEMBL858446

SCHEMBL858446

Cc1nc2ccccn2c1C=O

nearest known ligand 0.63

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 5/20 0.63
▸ NPC1 O15118 4/20 0.63
▸ RAB9A P51151 3/20 0.63
▸ KDM4E B2RXH2 5/20 0.55
▸ SMN1; SMN2 Q16637 2/20 0.55
▸ KMT2A Q03164 2/20 0.54
▸ NPSR1 Q6W5P4 5/20 0.50
▸ GAA P10253 2/20 0.49
▸ MAPK1 P28482 1/20 0.48
▸ MAPT P10636 1/20 0.47
▸ HSD17B10 Q99714 3/20 0.47
▸ HPGD P15428 2/20 0.47
▸ GLA P06280 1/20 0.47
▸ CASP1 P29466 1/20 0.47
▸ CASP7 P55210 1/20 0.47
▸ ENPP2 Q13822 1/20 0.47
▸ LMNA P02545 1/20 0.46
▸ HTT P42858 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27817071 0.84 KMT2A (0.51) ALDH1A1NPC1RAB9AKDM4ESMN1; SMN2
SCHEMBL12777904 0.79 ALDH1A1 (0.55) ALDH1A1NPC1RAB9AKDM4ESMN1; SMN2
SCHEMBL1664765 0.79 KDM4E (0.64) ALDH1A1NPC1RAB9AKDM4ESMN1; SMN2
SCHEMBL20377218 0.78 ALDH1A1 (0.55) ALDH1A1NPC1RAB9AKDM4ESMN1; SMN2
SCHEMBL28788575 0.78 ALDH1A1 (0.49) ALDH1A1NPC1RAB9AKDM4EKMT2A
SCHEMBL8313263 0.78 KMT2A (0.50) ALDH1A1NPC1RAB9AKDM4EKMT2A
SCHEMBL9587009 0.78 NPC1 (1.00) ALDH1A1NPC1RAB9AKDM4ESMN1; SMN2
SCHEMBL23531019 0.77 ALDH1A1 (0.56) ALDH1A1NPC1RAB9AKDM4ESMN1; SMN2
SCHEMBL4773388 0.76 ALDH1A1 (0.78) ALDH1A1NPC1RAB9AKDM4ESMN1; SMN2
SCHEMBL15331017 0.76 ALDH1A1 (0.49) ALDH1A1NPC1RAB9AKDM4ESMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 89 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113164458-B Monoacylglycerol lipase modulators 詹森药业有限公司 2024-09-13 — — CN claimed
CN-113164459-B Monoacylglycerol lipase modulators 詹森药业有限公司 2024-09-03 — — CN claimed
US-20120116027-A1 PROCESS FOR THE PURIFICATION OF HUMAN GROWTH HORMONE POLYPEPTIDES USING AFFINITY RESINS COMPRISING SPECIFIC LIGANDS NOVO NORDISK A/S (DK) 2012-05-10 — — US claimed
EP-2356141-A1 PROCESS FOR THE PURIFICATION OF HUMAN GROWTH HORMONE POLYPEPTIDES USING AFFINITY RESINS COMPRISING SPECIFIC LIGANDS Novo Nordisk A/S (DK) 2011-08-17 — — EP claimed
WO-2010055135-A1 PROCESS FOR THE PURIFICATION OF HUMAN GROWTH HORMONE POLYPEPTIDES USING AFFINITY RESINS COMPRISING SPECIFIC LIGANDS NOVO NORDISK A/S (DK) 2010-05-20 — — WO claimed
US-12577243-B2 Monoacylglycerol lipase modulators JANSSEN PHARMACEUTICA NV (BE) 2026-03-17 — — US disclosed
US-20240327410-A1 Monoacylglycerol Lipase Modulators JANSSEN PHARMACEUTICA NV (BE) 2024-10-03 — — US disclosed
CN-113164458-B Monoacylglycerol lipase modulators 詹森药业有限公司 2024-09-13 — — CN disclosed
CN-113164459-B Monoacylglycerol lipase modulators 詹森药业有限公司 2024-09-03 — — CN disclosed
US-11993601-B2 Monoacylglycerol lipase modulators JANSSEN PHARMACEUTICA NV 2024-05-28 — — US disclosed
US-11820766-B2 Monoacylglycerol lipase modulators JANSSEN PHARMACEUTICA NV (BE) 2023-11-21 — — US disclosed
US-20230242531-A1 Monoacylglycerol Lipase Modulators JANSSEN PHARMACEUTICA NV (BE) 2023-08-03 — — US disclosed
US-20090247547-A1 HYDROXAMATE-BASED INHIBITORS OF DEACETYLASES B NOVARTIS AG 2009-10-01 — — US disclosed
WO-2009118305-A1 HYDROXAMATE-BASED INHIBITORS OF DEACETYLASES B NOVARTIS AG (CH) 2009-10-01 — — WO disclosed
EP-0299470-B1 Imidazo[1,2-a]pyridines BYK GULDEN LOMBERG CHEM FAB (DE) 1996-12-04 — — EP disclosed
US-5112834-A Antisecretory and antiulcer BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) 1992-05-12 — — US disclosed
EP-0370056-A1 NEW DIAZOLS BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) 1990-05-30 — — EP disclosed
WO-1989000570-A1 NEW DIAZOLS BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) 1989-01-26 — — WO disclosed
EP-0299470-A1 Imidazo[1,2-a]pyridines Byk Gulden Lomberg Chemische Fabrik GmbH (DE) 1989-01-18 — — EP disclosed
EP-0290003-A2 Imidazoles Byk Gulden Lomberg Chemische Fabrik GmbH (DE) 1988-11-09 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230242531-A1 Monoacylglycerol Lipase Modulators MGLL, LPL, PNLIP ALDH1A1 344/4885NPC1 826/4885RAB9A 994/4885
US-12577243-B2 Monoacylglycerol lipase modulators MGLL, LPL, FAAH ALDH1A1 587/4885NPC1 212/4885RAB9A 1784/4885
US-20090247547-A1 HYDROXAMATE-BASED INHIBITORS OF DEACETYLASES B HDAC1, HDAC11, HDAC3 ALDH1A1 238/4885NPC1 602/4885RAB9A 2630/4885
US-20120116027-A1 PROCESS FOR THE PURIFICATION OF HUMAN GROWTH HORMONE POLYPEPTIDES USING AFFINITY RESINS COMPRISING SPECIFIC LIGANDS GHRHR, GHITM, GHSR ALDH1A1 4603/4885NPC1 4653/4885RAB9A 4091/4885
US-11993601-B2 Monoacylglycerol lipase modulators MGLL, LPL, PNLIP ALDH1A1 344/4885NPC1 826/4885RAB9A 994/4885
US-20240327410-A1 Monoacylglycerol Lipase Modulators MGLL, LPL, PNLIP ALDH1A1 344/4885NPC1 826/4885RAB9A 994/4885
US-11820766-B2 Monoacylglycerol lipase modulators MGLL, LPL, PNLIP ALDH1A1 312/4885NPC1 868/4885RAB9A 936/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.