Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | EEF2K | O00418 | 3/20 | 0.38 |
| ▸ | CASR | P41180 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | SNCA | P37840 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28564255 | 0.83 | LMNA (0.42) | HTTTSHRCYP1A2CYP2C19SMN1; SMN2 | |
| SCHEMBL21274711 | 0.82 | L3MBTL1 (0.39) | HTTEEF2KCASRL3MBTL1TSHR | |
| SCHEMBL7525829 | 0.76 | HTT (0.33) | HTTCYP1A2CYP2C19 | |
| SCHEMBL600325 | 0.76 | ALDH1A1 (0.36) | HTTCASRTSHRSNCA | |
| SCHEMBL8813449 | 0.76 | LMNA (0.43) | HTTTSHRCYP2C19SMN1; SMN2SNCA | |
| SCHEMBL9568576 | 0.75 | HTT (0.38) | HTTCASRTSHRCYP1A2CYP2C19 | |
| SCHEMBL776507 | 0.75 | HTT (0.39) | HTTCASRTSHRCYP1A2CYP2C19 | |
| SCHEMBL21910179 | 0.74 | IDO1 (0.47) | L3MBTL1TSHR | |
| SCHEMBL9615906 | 0.74 | HTT (0.43) | HTTTSHRSNCA | |
| SCHEMBL4687102 | 0.73 | SLC6A2 (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0701546-B1 | AROMATIC ACETYLCHOLINESTERASE INHIBITORS | MERRELL PHARMA INC (US) | 1998-12-23 | — | — | EP | disclosed |
| US-5663448-A | Aromatic acetylcholinesterase inhibitors | MERRELL PHARMACEUTICALS INC. (US) | 1997-09-02 | — | — | US | disclosed |
| EP-0701546-A1 | AROMATIC ACETYLCHOLINESTERASE INHIBITORS | MERRELL PHARMACEUTICALS INC. (US) | 1996-03-20 | — | — | EP | disclosed |
| WO-1994029255-A1 | AROMATIC ACETYLCHOLINESTERASE INHIBITORS | MERRELL PHARMACEUTICALS INC. (US) | 1994-12-22 | — | — | WO | disclosed |
| EP-0627400-A1 | Aromatic acetylcholinesterase inhibitors | MERRELL DOW PHARMACEUTICALS INC. (US) | 1994-12-07 | — | — | EP | disclosed |