Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | BRD4 | O60885 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8601552 | 0.92 | KDM4E (0.39) | KDM4EALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL8603828 | 0.90 | MTNR1A (0.38) | KDM4EALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL8602614 | 0.85 | AGER (0.40) | KDM4EALDH1A1LMNAPOLBMAPT | |
| SCHEMBL7352264 | 0.73 | KDM4E (0.52) | KDM4EALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL8970849 | 0.72 | KDM4E (0.50) | KDM4EALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL8602051 | 0.72 | MTNR1B (0.39) | KDM4EALDH1A1BRD4MTNR1AMTNR1B | |
| SCHEMBL8971582 | 0.69 | AGER (0.45) | ALDH1A1LMNAPOLBMAPTMEN1 | |
| SCHEMBL8811250 | 0.67 | ALDH1A1 (0.43) | ALDH1A1CYP1A2CYP3A4MAPTMEN1 | |
| SCHEMBL8812863 | 0.67 | PTGER1 (0.46) | CYP2C9MEN1KMT2A | |
| SCHEMBL25267903 | 0.67 | KDM4E (0.67) | KDM4EALDH1A1CYP1A2CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5763458-A | NERVOUS SYSTEM DISORDERS, ANXIETY, ANTIDEPRESSANTS AND COGNITION ACTIVATORS | SYNTEX (U.S.A.) INC. (US) | 1998-06-09 | — | — | US | disclosed |