Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 6/20 | 0.53 |
| ▸ | PIM2 | Q9P1W9 | 6/20 | 0.53 |
| ▸ | HPGD | P15428 | 7/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.45 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.45 |
| ▸ | IGF1R | P08069 | 1/20 | 0.44 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.44 |
| ▸ | MYC | P01106 | 1/20 | 0.44 |
| ▸ | NAT1 | P18440 | 1/20 | 0.44 |
| ▸ | MAX | P61244 | 1/20 | 0.44 |
| ▸ | MGAM | O43451 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | SI | P14410 | 1/20 | 0.43 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8614423 | 0.89 | CSNK2A2 (0.40) | PIM1PIM2HPGDNPC1HTT | |
| SCHEMBL8616364 | 0.88 | PIM1 (0.57) | PIM1PIM2HPGDNPC1RAB9A | |
| SCHEMBL8618308 | 0.88 | MTOR (0.47) | PIM1PIM2HPGDPPARGPIM3 | |
| SCHEMBL8640744 | 0.87 | HPGD (0.47) | PIM1PIM2HPGDNPC1HTT | |
| SCHEMBL8617896 | 0.87 | GSK3B (0.61) | PIM1PIM2HPGDNPC1HTT | |
| SCHEMBL8617338 | 0.84 | GSK3B (0.57) | PIM1PIM2HPGDNPC1HTT | |
| SCHEMBL8619012 | 0.83 | PTGS2 (0.60) | PIM1PIM2HPGDPPARGPIM3 | |
| SCHEMBL8620558 | 0.81 | CRHBP (0.60) | PIM1PIM2NPC1RAB9ACISD1 | |
| SCHEMBL8616362 | 0.77 | CLK1 (0.58) | PIM1PIM2HPGDNPC1RAB9A | |
| SCHEMBL8618302 | 0.77 | NPC1 (0.37) | HPGDNPC1RAB9APPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5767121-A | ANTIINFLAMMATORY AND -ARTHRITIC AGENTS; ANTIPYRETICS; ANALGESICS; ADHESION PROTEIN EXPRESSION AND CYCLOXYGENASE AND 5-LIPOXYGENASE INHIBITORS; IMMUNOSUPPRESSANTS AND -MODULATORS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-06-16 | — | — | US | disclosed |