Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 8/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 4/20 | 0.43 |
| ▸ | PIM2 | Q9P1W9 | 4/20 | 0.43 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.43 |
| ▸ | IGF1R | P08069 | 1/20 | 0.42 |
| ▸ | CISD1 | Q9NZ45 | 3/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8640740 | 0.89 | ALDH1A1 (0.45) | HPGDKDM4EALDH1A1LMNAMAPT | |
| SCHEMBL8614425 | 0.87 | PIM1 (0.53) | HPGDPPARGPIM1PIM2PIM3 | |
| SCHEMBL8616364 | 0.85 | PIM1 (0.57) | HPGDPPARGPIM1PIM2CISD1 | |
| SCHEMBL8618308 | 0.85 | MTOR (0.47) | HPGDPPARGPIM1PIM2PIM3 | |
| SCHEMBL8617896 | 0.85 | GSK3B (0.61) | HPGDMAPTTDP1L3MBTL1PPARG | |
| SCHEMBL8617338 | 0.83 | GSK3B (0.57) | HPGDLMNAMAPTTDP1PPARG | |
| SCHEMBL8619012 | 0.83 | PTGS2 (0.60) | HPGDPPARGPIM1PIM2PIM3 | |
| SCHEMBL8620558 | 0.79 | CRHBP (0.60) | PIM1PIM2CISD1MAOAGSK3B | |
| SCHEMBL8614423 | 0.77 | CSNK2A2 (0.40) | HPGDALDH1A1LMNAMAPTPPARG | |
| SCHEMBL8616362 | 0.75 | CLK1 (0.58) | HPGDKDM4EALDH1A1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5767121-A | ANTIINFLAMMATORY AND -ARTHRITIC AGENTS; ANTIPYRETICS; ANALGESICS; ADHESION PROTEIN EXPRESSION AND CYCLOXYGENASE AND 5-LIPOXYGENASE INHIBITORS; IMMUNOSUPPRESSANTS AND -MODULATORS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-06-16 | — | — | US | disclosed |