Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 2/20 | 0.57 |
| ▸ | NPC1 | O15118 | 5/20 | 0.44 |
| ▸ | RAB9A | P51151 | 4/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 5/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CISD1 | Q9NZ45 | 2/20 | 0.39 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8619553 | 0.88 | GSK3B (0.40) | GSK3BNPC1RAB9AHTTPIM1 | |
| SCHEMBL8618308 | 0.86 | MTOR (0.47) | PIM1MEN1KMT2AHPGDMTOR | |
| SCHEMBL8614425 | 0.84 | PIM1 (0.53) | NPC1RAB9AHTTPIM1HPGD | |
| SCHEMBL8640744 | 0.83 | HPGD (0.47) | GSK3BNPC1RAB9AHTTPIM1 | |
| SCHEMBL8616364 | 0.82 | PIM1 (0.57) | NPC1RAB9APIM1HPGDPOLB | |
| SCHEMBL8617896 | 0.82 | GSK3B (0.61) | GSK3BNPC1RAB9AHTTPIM1 | |
| SCHEMBL8619012 | 0.80 | PTGS2 (0.60) | PIM1HPGDPPARGPIM2 | |
| SCHEMBL8618302 | 0.76 | NPC1 (0.37) | GSK3BNPC1RAB9AMAPTKMT2A | |
| SCHEMBL8620558 | 0.76 | CRHBP (0.60) | GSK3BNPC1RAB9APIM1MEN1 | |
| SCHEMBL1250019 | 0.75 | GSK3B (1.00) | GSK3BNPC1RAB9AHTTPIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5767121-A | ANTIINFLAMMATORY AND -ARTHRITIC AGENTS; ANTIPYRETICS; ANALGESICS; ADHESION PROTEIN EXPRESSION AND CYCLOXYGENASE AND 5-LIPOXYGENASE INHIBITORS; IMMUNOSUPPRESSANTS AND -MODULATORS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-06-16 | — | — | US | disclosed |