Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHBP | P24387 | 3/20 | 0.60 |
| ▸ | CRHR2 | Q13324 | 3/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.51 |
| ▸ | PIM1 | P11309 | 2/20 | 0.47 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | MYC | P01106 | 1/20 | 0.47 |
| ▸ | MAX | P61244 | 1/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.46 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.46 |
| ▸ | CLK1 | P49759 | 1/20 | 0.46 |
| ▸ | CLK3 | P49761 | 1/20 | 0.46 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.46 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8614425 | 0.81 | PIM1 (0.53) | PIM1PIM2NPC1RAB9AMYC | |
| SCHEMBL8620079 | 0.81 | PTGS2 (0.61) | MEN1POLBKMT2APIM1PIM2 | |
| SCHEMBL8616364 | 0.79 | PIM1 (0.57) | POLBPIM1PIM2NPC1RAB9A | |
| SCHEMBL8618308 | 0.79 | MTOR (0.47) | MEN1KMT2APIM1PIM2PIK3CA | |
| SCHEMBL8640744 | 0.79 | HPGD (0.47) | MEN1KMT2APIM1PIM2NPC1 | |
| SCHEMBL8617896 | 0.79 | GSK3B (0.61) | MEN1KMT2APIM1PIM2NPC1 | |
| SCHEMBL194557 | 0.78 | CRHBP (1.00) | CRHBPCRHR2MEN1POLBKMT2A | |
| SCHEMBL194558 | 0.78 | CRHBP (1.00) | CRHBPCRHR2MEN1POLBKMT2A | |
| SCHEMBL1249935 | 0.78 | CRHBP (1.00) | CRHBPCRHR2MEN1POLBKMT2A | |
| SCHEMBL8617338 | 0.76 | GSK3B (0.57) | MEN1POLBKMT2APIM1PIM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5767121-A | ANTIINFLAMMATORY AND -ARTHRITIC AGENTS; ANTIPYRETICS; ANALGESICS; ADHESION PROTEIN EXPRESSION AND CYCLOXYGENASE AND 5-LIPOXYGENASE INHIBITORS; IMMUNOSUPPRESSANTS AND -MODULATORS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-06-16 | — | — | US | disclosed |