Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 4/20 | 0.57 |
| ▸ | PIM2 | Q9P1W9 | 4/20 | 0.57 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 7/20 | 0.55 |
| ▸ | PPARG | P37231 | 1/20 | 0.52 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.47 |
| ▸ | CLK1 | P49759 | 1/20 | 0.47 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.47 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.47 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8616362 | 0.89 | CLK1 (0.58) | PIM1PIM2AKR1B1NPC1RAB9A | |
| SCHEMBL8614425 | 0.88 | PIM1 (0.53) | PIM1PIM2NPC1RAB9AHPGD | |
| SCHEMBL8618308 | 0.86 | MTOR (0.47) | PIM1PIM2HPGDPPARGCISD1 | |
| SCHEMBL8617896 | 0.85 | GSK3B (0.61) | PIM1PIM2NPC1RAB9AHPGD | |
| SCHEMBL8640744 | 0.85 | HPGD (0.47) | PIM1PIM2NPC1RAB9AHPGD | |
| SCHEMBL8617338 | 0.82 | GSK3B (0.57) | PIM1PIM2NPC1RAB9AHPGD | |
| SCHEMBL8619012 | 0.82 | PTGS2 (0.60) | PIM1PIM2HPGDPPARGPTGS2 | |
| SCHEMBL8620558 | 0.79 | CRHBP (0.60) | PIM1PIM2NPC1RAB9ACISD1 | |
| SCHEMBL8614423 | 0.77 | CSNK2A2 (0.40) | PIM1PIM2NPC1RAB9AHPGD | |
| SCHEMBL8618302 | 0.76 | NPC1 (0.37) | NPC1RAB9AHPGDPPARGPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5767121-A | ANTIINFLAMMATORY AND -ARTHRITIC AGENTS; ANTIPYRETICS; ANALGESICS; ADHESION PROTEIN EXPRESSION AND CYCLOXYGENASE AND 5-LIPOXYGENASE INHIBITORS; IMMUNOSUPPRESSANTS AND -MODULATORS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-06-16 | — | — | US | disclosed |