Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 7/20 | 0.60 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.60 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | CTRC | Q99895 | 1/20 | 0.43 |
| ▸ | NAT1 | P18440 | 1/20 | 0.42 |
| ▸ | IGF1R | P08069 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.41 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8620079 | 0.91 | PTGS2 (0.61) | PTGS2PTGS1CTRCNAT1PIM1 | |
| SCHEMBL8619011 | 0.90 | PTGS2 (0.44) | PTGS2PTGS1CTRCIGF1R | |
| SCHEMBL8614425 | 0.83 | PIM1 (0.53) | HPGDNAT1IGF1RPPARGPIM1 | |
| SCHEMBL8640744 | 0.83 | HPGD (0.47) | HPGDIGF1RPPARGPIM1PIM3 | |
| SCHEMBL8616364 | 0.82 | PIM1 (0.57) | PTGS2HPGDPPARGPIM1PIM2 | |
| SCHEMBL8618308 | 0.81 | MTOR (0.47) | HPGDIGF1RPPARGPIM1PIM3 | |
| SCHEMBL8617896 | 0.81 | GSK3B (0.61) | HPGDPPARGPIM1PIM3PIM2 | |
| SCHEMBL8617338 | 0.80 | GSK3B (0.57) | HPGDPPARGPIM1PIM2 | |
| SCHEMBL3667218 | 0.77 | PTGS2 (1.00) | PTGS2PTGS1HPGDNAT1IGF1R | |
| SCHEMBL8962138 | 0.77 | PTGS2 (1.00) | PTGS2PTGS1HPGDNAT1IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5767121-A | ANTIINFLAMMATORY AND -ARTHRITIC AGENTS; ANTIPYRETICS; ANALGESICS; ADHESION PROTEIN EXPRESSION AND CYCLOXYGENASE AND 5-LIPOXYGENASE INHIBITORS; IMMUNOSUPPRESSANTS AND -MODULATORS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-06-16 | — | — | US | disclosed |