Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.39 |
| ▸ | LMNA | P02545 | 8/20 | 0.39 |
| ▸ | MEN1 | O00255 | 8/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 4/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.39 |
| ▸ | BLM | P54132 | 3/20 | 0.38 |
| ▸ | WRN | Q14191 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.38 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.38 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.38 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8616595 | 0.73 | LMNA (0.46) | MAPTKMT2ALMNAMEN1HTT | |
| SCHEMBL27783025 | 0.71 | MAPT (0.65) | MAPTKMT2ALMNAMEN1HTT | |
| SCHEMBL8118567 | 0.70 | MEN1 (0.50) | MAPTKMT2ALMNAMEN1HTT | |
| SCHEMBL8118565 | 0.69 | JAK2 (0.44) | MAPTKMT2ALMNAMEN1HTT | |
| SCHEMBL6998722 | 0.66 | ADORA2B (0.43) | MAPTKMT2AMEN1NPC1POLB | |
| SCHEMBL8115604 | 0.65 | ALDH1A1 (0.51) | MAPTKMT2ALMNAMEN1HTT | |
| SCHEMBL8616587 | 0.65 | HDAC2 (0.39) | KDM4EAAK1 | |
| SCHEMBL8589404 | 0.63 | GSTO1 (0.50) | MAPTKMT2ALMNAMEN1HTT | |
| SCHEMBL13949529 | 0.63 | MEN1 (0.66) | MAPTKMT2ALMNAMEN1HTT | |
| SCHEMBL16685574 | 0.62 | KMT2A (0.70) | MAPTKMT2ALMNAMEN1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998050346-A2 | ACETAMIDE AND UREA DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF CNS DISORDERS | SMITHKLINE BEECHAM PLC (GB) | 1998-11-12 | — | — | WO | disclosed |