Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 4/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | KDM1A | O60341 | 3/20 | 0.36 |
| ▸ | MAOB | P27338 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5509747 | 0.81 | L3MBTL1 (0.38) | TSHRL3MBTL1KDM4EMAOBTDP1 | |
| SCHEMBL8157082 | 0.76 | TSHR (0.44) | TSHRABCB1L3MBTL1KDM4EKDM1A | |
| SCHEMBL31563540 | 0.75 | L3MBTL1 (0.38) | TSHRL3MBTL1KDM4ETDP1NPC1 | |
| SCHEMBL2799853 | 0.75 | RAB9A (0.43) | TSHRL3MBTL1NPC1ALDH1A1LMNA | |
| SCHEMBL5860070 | 0.72 | TSHR (0.34) | TSHRL3MBTL1KDM4EKDM1AMAOB | |
| SCHEMBL12093550 | 0.71 | SLC13A5 (0.51) | KDM1AMAOBSLC6A2SLC6A4ADRA2A | |
| SCHEMBL5069502 | 0.70 | ALDH1A1 (0.35) | ALDH1A1MAPTSMN1; SMN2ADRA2AADRA2B | |
| SCHEMBL8584807 | 0.69 | ALOX5 (0.41) | — | |
| SCHEMBL28301401 | 0.67 | PPARA (0.43) | TDP1POLB | |
| SCHEMBL19604959 | 0.66 | NOS2 (0.58) | KDM4EALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0835258-A1 | NOVEL CAMPTOTHECIN ANALOGUES, PREPARATION METHODS THEREFOR, USE THEREOF AS DRUGS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAID ANALOGUES | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (S.C.R.A.S.) (FR) | 1998-04-15 | — | — | EP | disclosed |
| WO-1997000876-A1 | NOVEL CAMPTOTHECIN ANALOGUES, PREPARATION METHODS THEREFOR, USE THEREOF AS DRUGS, AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAID ANALOGUES | SOCIETE DE CONSEILS DE RECHERCHES ET D'APPLICATIONS SCIENTIFIQUES (SCRAS) (FR) | 1997-01-09 | — | — | WO | disclosed |