Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.38 |
| ▸ | DRD4 | P21917 | 3/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.38 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8628029 | 0.85 | DRD2 (0.46) | DHFRHRH3PPARAPOLBRECQL | |
| SCHEMBL8630582 | 0.85 | MAPT (0.54) | MAPTNPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL8630532 | 0.82 | DRD2 (0.46) | MAPTALDH1A1POLBRECQLHSD17B10 | |
| SCHEMBL8633168 | 0.82 | HTR3A (0.55) | MAPTALDH1A1POLBRECQLHSD17B10 | |
| SCHEMBL8628179 | 0.81 | KDM4E (0.50) | MAPTALDH1A1SMN1; SMN2POLBHSD17B10 | |
| SCHEMBL8634968 | 0.80 | DRD4 (0.57) | MAPTALDH1A1SMN1; SMN2POLBHSD17B10 | |
| Hydrochloric Acid SCHEMBL8629946 | 0.79 | DRD4 (0.56) | MAPTALDH1A1SMN1; SMN2POLBHSD17B10 | |
| SCHEMBL8631634 | 0.77 | HRH3 (0.59) | HRH3NPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL8627836 | 0.75 | DRD4 (0.45) | MAPTNPC1RAB9AALDH1A1POLB | |
| SCHEMBL8633681 | 0.75 | RECQL (0.50) | POLBRECQLHSD17B10L3MBTL1DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5780475-A | Antipsychotic indazole derivatives | MERCK, SHARP & DOHME LIMITED (GB) | 1998-07-14 | — | — | US | disclosed |