Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 1/20 | 0.55 |
| ▸ | RECQL | P46063 | 2/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | KMO | O15229 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8628179 | 0.83 | KDM4E (0.50) | POLBHSD17B10KCNH2HTR1ADRD2 | |
| SCHEMBL8628029 | 0.82 | DRD2 (0.46) | HTR3ARECQLP2RX7POLBHSD17B10 | |
| SCHEMBL8630532 | 0.82 | DRD2 (0.46) | RECQLP2RX7POLBHSD17B10L3MBTL1 | |
| SCHEMBL8628045 | 0.82 | DHFR (0.43) | HTR3ARECQLP2RX7POLBHSD17B10 | |
| SCHEMBL8632193 | 0.80 | KDM4E (0.52) | LRRK2HSD17B10L3MBTL1CXCR3DRD2 | |
| SCHEMBL8627836 | 0.80 | DRD4 (0.45) | HTR3ARECQLP2RX7POLBHSD17B10 | |
| SCHEMBL8634968 | 0.80 | DRD4 (0.57) | POLBHSD17B10L3MBTL1CYP1A2MAPT | |
| SCHEMBL8633681 | 0.80 | RECQL (0.50) | RECQLP2RX7POLBHSD17B10L3MBTL1 | |
| SCHEMBL8631634 | 0.80 | HRH3 (0.59) | HTR3ARECQLHSD17B10CYP1A2HTR1A | |
| Hydrochloric Acid SCHEMBL8629946 | 0.79 | DRD4 (0.56) | POLBHSD17B10L3MBTL1CYP1A2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5780475-A | Antipsychotic indazole derivatives | MERCK, SHARP & DOHME LIMITED (GB) | 1998-07-14 | — | — | US | disclosed |