Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.46 |
| ▸ | DRD3 | P35462 | 4/20 | 0.46 |
| ▸ | DRD4 | P21917 | 3/20 | 0.46 |
| ▸ | DRD1 | P21728 | 3/20 | 0.44 |
| ▸ | DRD5 | P21918 | 3/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | HTR7 | P34969 | 1/20 | 0.44 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.43 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.43 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.43 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.43 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.43 |
| ▸ | DHFR | P00374 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8630532 | 0.85 | DRD2 (0.46) | DRD2DRD3DRD4HTR1AHTR2A | |
| SCHEMBL8628045 | 0.85 | DHFR (0.43) | DRD2DRD3DRD4DRD1HTR1A | |
| SCHEMBL8631570 | 0.84 | MAPT (0.47) | DRD2DRD3DRD4HTR1ASLC6A4 | |
| SCHEMBL8628179 | 0.84 | KDM4E (0.50) | DRD2DRD3DRD4HTR1ASLC6A4 | |
| SCHEMBL8633168 | 0.82 | HTR3A (0.55) | DRD2DRD3HTR1AHTR2AHTR2C | |
| SCHEMBL8634968 | 0.82 | DRD4 (0.57) | DRD4POLBHSD17B10L3MBTL1GRM2 | |
| Hydrochloric Acid SCHEMBL8629946 | 0.81 | DRD4 (0.56) | DRD4POLBHSD17B10L3MBTL1GRM2 | |
| SCHEMBL8631634 | 0.80 | HRH3 (0.59) | HTR1AHTR2CSLC6A4HTR7RECQL | |
| SCHEMBL8628296 | 0.79 | HTR7 (0.45) | DRD2DRD3HTR1AHTR7RECQL | |
| SCHEMBL8627836 | 0.78 | DRD4 (0.45) | DRD2DRD3DRD4HTR1ARECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5780475-A | Antipsychotic indazole derivatives | MERCK, SHARP & DOHME LIMITED (GB) | 1998-07-14 | — | — | US | disclosed |