Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 1/20 | 0.57 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 5/20 | 0.48 |
| ▸ | LMNA | P02545 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.46 |
| ▸ | SMO | Q99835 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8629946 | 0.99 | DRD4 (0.56) | DRD4GRM2HTTLMNAALDH1A1 | |
| SCHEMBL8632193 | 0.84 | KDM4E (0.52) | DRD4GRM2LMNAALDH1A1MAPT | |
| SCHEMBL8628029 | 0.82 | DRD2 (0.46) | DRD4GRM2L3MBTL1TSHRHSD17B10 | |
| SCHEMBL8630532 | 0.82 | DRD2 (0.46) | DRD4ALDH1A1KMT2AMAPTL3MBTL1 | |
| SCHEMBL8628212 | 0.81 | SMO (0.42) | DRD4GRM2SMOL3MBTL1KDM4E | |
| SCHEMBL8628179 | 0.81 | KDM4E (0.50) | DRD4GRM2LMNAALDH1A1KMT2A | |
| SCHEMBL8633168 | 0.80 | HTR3A (0.55) | LMNAALDH1A1MAPTL3MBTL1TSHR | |
| SCHEMBL8630535 | 0.80 | SIGMAR1 (0.53) | ALDH1A1SMN1; SMN2SMOMAPTKDM4E | |
| SCHEMBL8628045 | 0.80 | DHFR (0.43) | DRD4GRM2LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL8631634 | 0.77 | HRH3 (0.59) | HTTLMNAALDH1A1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5780475-A | Antipsychotic indazole derivatives | MERCK, SHARP & DOHME LIMITED (GB) | 1998-07-14 | — | — | US | disclosed |