Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K4 | P45985 | 4/20 | 0.45 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.45 |
| ▸ | KAT6A | Q92794 | 2/20 | 0.44 |
| ▸ | PGR | P06401 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.42 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.41 |
| ▸ | ACLY | P53396 | 1/20 | 0.40 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.40 |
| ▸ | KIT | P10721 | 2/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | IDH2 | P48735 | 1/20 | 0.39 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8632286 | 0.87 | KIT (0.45) | PGRPIK3CAKITPIK3CDPIK3CB | |
| SCHEMBL8631178 | 0.86 | STAT3 (0.47) | MAP2K4MAPK14KITKDR | |
| SCHEMBL8631659 | 0.85 | NAT1 (0.53) | KAT6APGRPTPN1ACLYPIK3CA | |
| SCHEMBL8631345 | 0.85 | MCL1 (0.49) | PTPN1PTPN5 | |
| SCHEMBL8632810 | 0.84 | STAT3 (0.42) | MAPK14KIT | |
| SCHEMBL8759075 | 0.84 | MCL1 (0.41) | MAP2K4MAP2K7MAPK14PTGES2PIK3CA | |
| SCHEMBL8631496 | 0.81 | MAPK14 (0.43) | MAP2K4MAP2K7MAPK14PIK3CAPIK3CD | |
| SCHEMBL8629318 | 0.80 | PTGS2 (0.50) | MAPK14ACLYPIK3CAKITNTRK1 | |
| SCHEMBL8630028 | 0.80 | ALDH1A1 (0.45) | PIK3CAKITNTRK1KDR | |
| SCHEMBL8631080 | 0.80 | KMO (0.52) | PGRPTGES2ACLYPIK3CAPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756530-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G. D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |