Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 5/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | SQSTM1 | Q13501 | 1/20 | 0.50 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.50 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8759590 | 0.94 | KMT2A (0.52) | MAPTKMT2AMEN1RXFP1LMNA | |
| SCHEMBL8632624 | 0.91 | SMN1; SMN2 (0.48) | MAPTKMT2AMEN1RXFP1LMNA | |
| SCHEMBL8632208 | 0.86 | STAT3 (0.51) | MAPTKMT2ALMNASQSTM1KEAP1 | |
| SCHEMBL8632286 | 0.85 | KIT (0.45) | MAPTKMT2AMEN1RXFP1LMNA | |
| SCHEMBL8632837 | 0.84 | LMNA (0.51) | MAPTKMT2AMEN1LMNAKDM4E | |
| SCHEMBL8627973 | 0.81 | KDM1A (0.51) | MAPTKMT2AMEN1RXFP1LMNA | |
| SCHEMBL8631178 | 0.81 | STAT3 (0.47) | MAPTKMT2AMEN1RXFP1LMNA | |
| SCHEMBL8634763 | 0.81 | NAT1 (0.45) | MAPTKMT2AMEN1RXFP1KDM4E | |
| SCHEMBL8632960 | 0.81 | KEAP1 (0.51) | MAPTKMT2AMEN1LMNAKDM4E | |
| SCHEMBL8631560 | 0.81 | SLC40A1 (0.44) | MAPTTP53SLC40A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756530-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G. D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |