Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | CA12 | O43570 | 2/20 | 0.51 |
| ▸ | CA2 | P00918 | 2/20 | 0.51 |
| ▸ | CA9 | Q16790 | 2/20 | 0.51 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.51 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.45 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
| ▸ | KIT | P10721 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8632286 | 0.90 | KIT (0.45) | LMNACA12CA2CA9MCOLN3 | |
| SCHEMBL8632208 | 0.87 | STAT3 (0.51) | LMNAMAPTPOLBALDH1A1KMT2A | |
| SCHEMBL8631178 | 0.86 | STAT3 (0.47) | LMNAMAPTPOLBMEN1KMT2A | |
| SCHEMBL8632960 | 0.86 | KEAP1 (0.51) | LMNAMAPTPOLBALDH1A1CYP2C9 | |
| SCHEMBL8634763 | 0.86 | NAT1 (0.45) | CA12CA2CA9CA1MAPT | |
| SCHEMBL8627973 | 0.86 | KDM1A (0.51) | LMNAMAPTPOLBALDH1A1MEN1 | |
| SCHEMBL8630028 | 0.86 | ALDH1A1 (0.45) | LMNAMCOLN3MAPTALDH1A1L3MBTL1 | |
| SCHEMBL8631345 | 0.86 | MCL1 (0.49) | LMNACA12CA2CA9MCOLN3 | |
| SCHEMBL8628203 | 0.86 | ALDH1A1 (0.46) | LMNAMAPTPOLBALDH1A1MEN1 | |
| SCHEMBL8630955 | 0.85 | IMPDH2 (0.54) | LMNAKITKDRCKS1BSKP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756530-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G. D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |