Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT3 | P40763 | 3/20 | 0.51 |
| ▸ | PGR | P06401 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | CKS1B | P61024 | 1/20 | 0.47 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.47 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.47 |
| ▸ | SQSTM1 | Q13501 | 1/20 | 0.47 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.46 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.46 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.46 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.46 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.46 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.46 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.46 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8632286 | 0.88 | KIT (0.45) | PGRKEAP1MAPTLMNAKMT2A | |
| SCHEMBL8632837 | 0.87 | LMNA (0.51) | POLBCKS1BSKP2KEAP1NFE2L2 | |
| SCHEMBL8631402 | 0.86 | MAPT (0.57) | KEAP1SQSTM1NFE2L2MAPTLMNA | |
| SCHEMBL8632624 | 0.84 | SMN1; SMN2 (0.48) | MAPTSMN1; SMN2LMNAPRKAA1KMT2A | |
| SCHEMBL8631178 | 0.84 | STAT3 (0.47) | STAT3POLBKEAP1NFE2L2MAPT | |
| SCHEMBL8627973 | 0.84 | KDM1A (0.51) | PGRPOLBMAPTLMNAKMT2A | |
| SCHEMBL8634763 | 0.84 | NAT1 (0.45) | KEAP1MAPTSMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL8632960 | 0.84 | KEAP1 (0.51) | POLBKEAP1MAPTSMN1; SMN2LMNA | |
| SCHEMBL8631560 | 0.84 | SLC40A1 (0.44) | MAPTTP53FFAR4 | |
| SCHEMBL8628203 | 0.84 | ALDH1A1 (0.46) | POLBMAPTSMN1; SMN2LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756530-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G. D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |