Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PI4KB | Q9UBF8 | 6/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | ACLY | P53396 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.38 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | EDNRA | P25101 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8635131 | 0.91 | PI4KB (0.43) | PI4KBACLYPTGS2PTGS1SMN1; SMN2 | |
| SCHEMBL8631448 | 0.89 | SMN1; SMN2 (0.40) | PI4KBHTR6ACLYPTGS2PTGS1 | |
| SCHEMBL8635623 | 0.89 | PI4KB (0.44) | PI4KBHTR6ACLYTP53MDM2 | |
| SCHEMBL8632918 | 0.86 | PI4KB (0.41) | PI4KBHTR6ACLYTP53MDM2 | |
| SCHEMBL8630165 | 0.86 | ACLY (0.39) | PI4KBHTR6ACLYPTGS2PTGS1 | |
| SCHEMBL8627805 | 0.86 | PI4KB (0.38) | PI4KBHTR6ACLYPTGS2PTGS1 | |
| SCHEMBL8634716 | 0.85 | PI4KB (0.42) | PI4KBHTR6ACLYKDRPTGS2 | |
| SCHEMBL8631050 | 0.85 | PTGS2 (0.42) | PI4KBHTR6ACLYTP53MDM2 | |
| SCHEMBL8631464 | 0.85 | PI4KB (0.40) | PI4KBHTR6ACLYTP53MDM2 | |
| SCHEMBL8631784 | 0.84 | GAA (0.44) | TP53PTGS2SMN1; SMN2ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756530-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G. D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |