Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.35 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.35 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.34 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.34 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8634234 | 0.86 | MEN1 (0.36) | MEN1KMT2AESR1POLBGAA | |
| SCHEMBL8635496 | 0.86 | ALDH1A1 (0.39) | KMT2ASLC9A1POLBKCNJ6KCNJ5 | |
| SCHEMBL8635012 | 0.85 | NSD2 (0.36) | ESR1SLC9A1POLBGAA | |
| SCHEMBL8638262 | 0.84 | HPGD (0.39) | MEN1KMT2APOLB | |
| SCHEMBL7765580 | 0.84 | SLC9A1 (0.58) | SLC9A1 | |
| SCHEMBL8635768 | 0.83 | ALDH1A1 (0.37) | SLC9A1POLB | |
| SCHEMBL8632865 | 0.83 | RORC (0.36) | KMT2AESR1 | |
| SCHEMBL8635629 | 0.81 | FLT1 (0.36) | SLC9A1POLBKCNJ6KCNJ5KCNJ3 | |
| SCHEMBL8638285 | 0.81 | PDE4B (0.41) | MEN1KMT2A | |
| SCHEMBL8634361 | 0.80 | BRD4 (0.39) | MEN1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1057999-C | 4-Aminobenzoylguanidine derivatives | MERCK PATENT GMBH (DE) | 2000-11-01 | — | — | CN | disclosed |
| US-5739142-A | 4-aminobenzoylguanidine derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-04-14 | — | — | US | disclosed |
| CN-1138575-A | 4-aminobenzoylguanidine derivatives | MERCK PATENT GMBH (DE) | 1996-12-25 | — | — | CN | disclosed |