Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | GPBAR1 | Q8TDU6 | 8/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8633152 | 0.88 | RORC (0.38) | RORCSMN1; SMN2HDAC6ESR1 | |
| SCHEMBL8635496 | 0.85 | ALDH1A1 (0.39) | KMT2AMAPT | |
| SCHEMBL7765490 | 0.84 | SLC9A1 (0.55) | — | |
| SCHEMBL8633203 | 0.83 | MEN1 (0.35) | ESR1KMT2A | |
| SCHEMBL8635012 | 0.81 | NSD2 (0.36) | ESR1MAPT | |
| SCHEMBL8635732 | 0.81 | KCNJ6 (0.38) | GPBAR1 | |
| SCHEMBL8638262 | 0.81 | HPGD (0.39) | KMT2AMAPT | |
| SCHEMBL8635768 | 0.80 | ALDH1A1 (0.37) | HDAC6 | |
| SCHEMBL8635192 | 0.76 | RXRA (0.35) | GPBAR1KMT2A | |
| SCHEMBL8634361 | 0.76 | BRD4 (0.39) | SMN1; SMN2KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5739142-A | 4-aminobenzoylguanidine derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1998-04-14 | — | — | US | disclosed |