Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | APEX1 | P27695 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8632206 | 0.79 | LMNA (0.37) | DRD2CYP1A2HTR1ACYP2D6PKM | |
| SCHEMBL8631076 | 0.76 | DRD2 (0.36) | DRD2CYP1A2HTR1ACYP2D6PKM | |
| SCHEMBL8633421 | 0.74 | HTR1A (0.51) | DRD2CYP1A2HTR1ACYP2D6TSHR | |
| SCHEMBL8631128 | 0.66 | HTR1D (0.35) | DRD2HTR1A | |
| SCHEMBL9449401 | 0.66 | DRD2 (0.40) | DRD2HTR1ADRD3 | |
| SCHEMBL7335068 | 0.66 | DRD2 (0.51) | DRD2HTR1ADRD3 | |
| SCHEMBL8312041 | 0.66 | HTR1A (0.51) | DRD2CYP1A2HTR1ACYP2D6TSHR | |
| SCHEMBL8317710 | 0.65 | VCAM1 (0.37) | DRD2HTR1A | |
| SCHEMBL8318624 | 0.64 | HTR1A (0.44) | DRD2CYP1A2HTR1ACYP2D6TSHR | |
| SCHEMBL7331680 | 0.63 | DRD2 (0.47) | DRD2HTR1ADRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0683155-B1 | Tetrahydrobenz cd indoles with serotonin regulatory activity | LILLY CO ELI (US) | 1998-07-01 | — | — | EP | disclosed |
| EP-0683155-A1 | Tetrahydrobenz cd indoles with serotonin regulatory activity | ELI LILLY AND COMPANY (US) | 1995-11-22 | — | — | EP | disclosed |
| US-5385928-A | Antiserotonine agent | ELI LILLY AND COMPANY (US) | 1995-01-31 | — | — | US | disclosed |