Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.49 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.49 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.49 |
| ▸ | DRD3 | P35462 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.37 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8638972 | 0.74 | PDCD1 (0.46) | SIGMAR1HTR1AADRA2ADRD2ADRA2C | |
| SCHEMBL7805194 | 0.73 | SIGMAR1 (0.70) | SIGMAR1HTR1AADRA2ADRD2ADRA2C | |
| SCHEMBL8638929 | 0.70 | HTR1A (0.50) | SIGMAR1HTR1AADRA2ADRD2ADRA2C | |
| SCHEMBL3143023 | 0.69 | CYP2D6 (0.68) | SIGMAR1DRD2ADRA2CDRD3CYP2D6 | |
| SCHEMBL8639458 | 0.69 | HRH3 (0.39) | SIGMAR1HTR1AADRA2ADRD2ADRA2C | |
| SCHEMBL3771402 | 0.67 | SIGMAR1 (0.61) | SIGMAR1HTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL7810984 | 0.66 | DRD2 (1.00) | SIGMAR1HTR1AADRA2ADRD2ADRA2C | |
| SCHEMBL29639702 | 0.66 | DRD2 (1.00) | SIGMAR1HTR1AADRA2ADRD2ADRA2C | |
| SCHEMBL7814547 | 0.66 | SIGMAR1 (0.65) | SIGMAR1HTR1AADRA2ADRD2ADRA2C | |
| SCHEMBL11518881 | 0.65 | CYP2D6 (0.60) | SIGMAR1ADRA2CCYP2D6HRH3TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5753662-A | TREATING DOPAMINERGIC SYSTEM DISORDERS | ADIR ET COMPAGNIE (FR) | 1998-05-19 | — | — | US | disclosed |
| US-5684020-A | ANTIPSYCHOTICS, ANTIDEPRESSANTS, TREATMENT OF DYSFUNCTION OF DOPAMINERGIC SYSTEM | ADIR ET COMPAGNIE (FR) | 1997-11-04 | — | — | US | disclosed |