Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.50 |
| ▸ | DRD2 | P14416 | 1/20 | 0.50 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.50 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.50 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.50 |
| ▸ | DRD3 | P35462 | 1/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 12/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 12/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 12/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8637762 | 0.76 | DRD2 (0.36) | HTR1AADRA2ADRD2ADRA2CADRA1D | |
| SCHEMBL7814547 | 0.73 | SIGMAR1 (0.65) | HTR1AADRA2ADRD2ADRA2CADRA1D | |
| SCHEMBL8636240 | 0.70 | SIGMAR1 (0.49) | HTR1AADRA2ADRD2ADRA2CADRA1D | |
| SCHEMBL29639702 | 0.67 | DRD2 (1.00) | HTR1AADRA2ADRD2ADRA2CADRA1D | |
| SCHEMBL7810984 | 0.67 | DRD2 (1.00) | HTR1AADRA2ADRD2ADRA2CADRA1D | |
| SCHEMBL7805194 | 0.67 | SIGMAR1 (0.70) | HTR1AADRA2ADRD2ADRA2CADRA1D | |
| SCHEMBL8638972 | 0.65 | PDCD1 (0.46) | HTR1AADRA2ADRD2ADRA2CADRA1D | |
| SCHEMBL7805256 | 0.65 | DRD2 (0.72) | HTR1AADRA2ADRD2ADRA2CADRA1D | |
| SCHEMBL7807312 | 0.63 | HTR1A (0.84) | HTR1AADRA2ADRD2ADRA2CADRA1D | |
| SCHEMBL4822071 | 0.62 | SLC6A2 (0.60) | SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5753662-A | TREATING DOPAMINERGIC SYSTEM DISORDERS | ADIR ET COMPAGNIE (FR) | 1998-05-19 | — | — | US | disclosed |
| US-5684020-A | ANTIPSYCHOTICS, ANTIDEPRESSANTS, TREATMENT OF DYSFUNCTION OF DOPAMINERGIC SYSTEM | ADIR ET COMPAGNIE (FR) | 1997-11-04 | — | — | US | disclosed |