Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDCD1 | Q15116 | 1/20 | 0.46 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 6/20 | 0.43 |
| ▸ | DRD2 | P14416 | 4/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 5/20 | 0.40 |
| ▸ | HTR2C | P28335 | 3/20 | 0.40 |
| ▸ | HTR7 | P34969 | 4/20 | 0.36 |
| ▸ | DRD1 | P21728 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8636240 | 0.74 | SIGMAR1 (0.49) | PDCD1CD274HTR1ADRD2SIGMAR1 | |
| SCHEMBL7812220 | 0.73 | DRD2 (0.64) | HTR1ADRD2SIGMAR1ADRA2AADRA2C | |
| SCHEMBL8639458 | 0.71 | HRH3 (0.39) | PDCD1CD274HTR1ADRD2SIGMAR1 | |
| SCHEMBL8637762 | 0.68 | DRD2 (0.36) | PDCD1CD274HTR1ADRD2SIGMAR1 | |
| SCHEMBL8638929 | 0.65 | HTR1A (0.50) | HTR1ADRD2SIGMAR1ADRA2AADRA2C | |
| SCHEMBL7812383 | 0.64 | HTR3A (0.54) | HTR1ADRD2SIGMAR1DRD3HTR2A | |
| SCHEMBL7805133 | 0.64 | DRD2 (0.55) | HTR1ADRD2SIGMAR1ADRA2AADRA2C | |
| SCHEMBL7820560 | 0.61 | ADRA1D (0.48) | HTR1ADRD2SIGMAR1ADRA2AADRA2C | |
| SCHEMBL7820563 | 0.61 | ADRA1D (0.48) | HTR1ADRD2SIGMAR1ADRA2AADRA2C | |
| SCHEMBL7805194 | 0.60 | SIGMAR1 (0.70) | HTR1ADRD2SIGMAR1ADRA2AADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5753662-A | TREATING DOPAMINERGIC SYSTEM DISORDERS | ADIR ET COMPAGNIE (FR) | 1998-05-19 | — | — | US | disclosed |
| US-5684020-A | ANTIPSYCHOTICS, ANTIDEPRESSANTS, TREATMENT OF DYSFUNCTION OF DOPAMINERGIC SYSTEM | ADIR ET COMPAGNIE (FR) | 1997-11-04 | — | — | US | disclosed |