Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.37 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.37 |
| ▸ | GSK3A | P49840 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.31 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7805320 | 0.72 | SIGMAR1 (0.71) | SIGMAR1HTR1AADRA2ADRD2ADRA2C | |
| SCHEMBL8638972 | 0.71 | PDCD1 (0.46) | SIGMAR1HTR1AADRA2ADRD2ADRA2C | |
| SCHEMBL8636240 | 0.69 | SIGMAR1 (0.49) | HRH3SIGMAR1HTR1AADRA2ADRD2 | |
| SCHEMBL7805322 | 0.68 | DRD2 (0.71) | SIGMAR1HTR1AADRA2ADRD2ADRA2C | |
| SCHEMBL7820563 | 0.64 | ADRA1D (0.48) | SIGMAR1HTR1AADRA2ADRD2ADRA2C | |
| SCHEMBL7820560 | 0.64 | ADRA1D (0.48) | SIGMAR1HTR1AADRA2ADRD2ADRA2C | |
| SCHEMBL7818191 | 0.64 | ADRB1 (0.44) | SIGMAR1HTR1ATGFBR1ACVR1 | |
| SCHEMBL9175108 | 0.60 | ADRB1 (0.62) | SIGMAR1HTR1ADRD2DRD3 | |
| SCHEMBL8638929 | 0.59 | HTR1A (0.50) | HRH3SIGMAR1HTR1AADRA2ADRD2 | |
| SCHEMBL5791140 | 0.59 | HRH3 (0.55) | HRH3HTR1ACHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5753662-A | TREATING DOPAMINERGIC SYSTEM DISORDERS | ADIR ET COMPAGNIE (FR) | 1998-05-19 | — | — | US | disclosed |
| US-5684020-A | ANTIPSYCHOTICS, ANTIDEPRESSANTS, TREATMENT OF DYSFUNCTION OF DOPAMINERGIC SYSTEM | ADIR ET COMPAGNIE (FR) | 1997-11-04 | — | — | US | disclosed |