Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 4/20 | 0.32 |
| ▸ | ITGA2B | P08514 | 4/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | RAB9A | P51151 | 5/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 4/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.31 |
| ▸ | LMNA | P02545 | 3/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | PKM | P14618 | 2/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8635712 | 0.92 | MAPT (0.32) | ITGB3ITGA2BALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL8638609 | 0.87 | CYP1A2 (0.40) | ALDH1A1SMN1; SMN2NPSR1MAPTHSD17B10 | |
| SCHEMBL8640371 | 0.85 | — | — | |
| SCHEMBL8638962 | 0.83 | SMN1; SMN2 (0.36) | ALDH1A1RAB9ASMN1; SMN2NPC1KMT2A | |
| SCHEMBL8638777 | 0.81 | MAOA (0.38) | KMT2AMEN1 | |
| SCHEMBL9004609 | 0.80 | ALDH1A1 (0.33) | ALDH1A1RAB9ASMN1; SMN2NPSR1NPC1 | |
| SCHEMBL8636623 | 0.79 | CASP6 (0.41) | ALDH1A1RAB9ASMN1; SMN2NPSR1NPC1 | |
| SCHEMBL9166368 | 0.79 | ACHE (0.32) | ALDH1A1LMNAMAPK1 | |
| SCHEMBL8641204 | 0.79 | ACHE (0.38) | ALDH1A1KMT2AMEN1 | |
| SCHEMBL9167754 | 0.79 | ALDH1A1 (0.36) | ALDH1A1RAB9ASMN1; SMN2NPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5480882-A | Benzoxazinone and benzothiazinone derivatives having cardiovascular activity | ITALFARMACO S.P.A. (IT) | 1996-01-02 | — | — | US | claimed |
| EP-0566018-B1 | Benzoxazinone and benzothiazinone derivatives endowed with cardiovascular activity | ITALFARMACO SPA (IT) | 1998-08-05 | — | — | EP | disclosed |
| US-5480882-A | Benzoxazinone and benzothiazinone derivatives having cardiovascular activity | ITALFARMACO S.P.A. (IT) | 1996-01-02 | — | — | US | disclosed |