Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.37 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8636623 | 0.92 | CASP6 (0.41) | CYP1A2CYP2C19NPSR1ALDH1A1HPGD | |
| SCHEMBL8638962 | 0.88 | SMN1; SMN2 (0.36) | CYP2C19ALDH1A1MAPTHTTMAPK1 | |
| SCHEMBL8637410 | 0.87 | ITGB3 (0.32) | NPSR1ALDH1A1HSD17B10MAPTMAPK1 | |
| SCHEMBL8640371 | 0.83 | — | — | |
| SCHEMBL8658972 | 0.82 | SMN1; SMN2 (0.39) | NPSR1ALDH1A1KDM4EMAPTHTT | |
| SCHEMBL9167754 | 0.82 | ALDH1A1 (0.36) | ALDH1A1KDM4ESMN1; SMN2ACHE | |
| SCHEMBL8638777 | 0.82 | MAOA (0.38) | — | |
| SCHEMBL8640361 | 0.81 | PLCG1 (0.40) | CYP2C19ALDH1A1MAPTHTTMAPK1 | |
| SCHEMBL9170026 | 0.80 | ROCK2 (0.40) | ALDH1A1KDM4EMAPTSMN1; SMN2ACHE | |
| SCHEMBL9166368 | 0.79 | ACHE (0.32) | ALDH1A1MAPK1POLBACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5480882-A | Benzoxazinone and benzothiazinone derivatives having cardiovascular activity | ITALFARMACO S.P.A. (IT) | 1996-01-02 | — | — | US | claimed |
| EP-0566018-B1 | Benzoxazinone and benzothiazinone derivatives endowed with cardiovascular activity | ITALFARMACO SPA (IT) | 1998-08-05 | — | — | EP | disclosed |
| US-5480882-A | Benzoxazinone and benzothiazinone derivatives having cardiovascular activity | ITALFARMACO S.P.A. (IT) | 1996-01-02 | — | — | US | disclosed |
| EP-0566018-A2 | Benzoxazinone and benzothiazinone derivatives endowed with cardiovascular activity | ITALFARMACO S.p.A. (IT) | 1993-10-20 | — | — | EP | disclosed |