Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.52 |
| ▸ | HTR2C | P28335 | 5/20 | 0.50 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.49 |
| ▸ | PNMT | P11086 | 3/20 | 0.47 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 4/20 | 0.43 |
| ▸ | HTR2B | P41595 | 4/20 | 0.43 |
| ▸ | HTR7 | P34969 | 3/20 | 0.43 |
| ▸ | HTR6 | P50406 | 2/20 | 0.43 |
| ▸ | HTR3A | P46098 | 1/20 | 0.43 |
| ▸ | HTR1D | P28221 | 1/20 | 0.42 |
| ▸ | HTR1E | P28566 | 1/20 | 0.42 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27926376 | 0.86 | SIGMAR1 (0.55) | SIGMAR1HTR2CSOS1PNMTASIC3 | |
| SCHEMBL8635851 | 0.78 | HTR2A (0.42) | HTR2CHTR2AHTR2BHTR7HTR6 | |
| SCHEMBL8350829 | 0.78 | AHR (0.48) | HTR2CPNMTASIC3HTR2AHTR2B | |
| SCHEMBL27676378 | 0.77 | PRCP (0.48) | SIGMAR1HTR2CPNMTHTR7 | |
| SCHEMBL8639724 | 0.76 | HTR2C (0.56) | SIGMAR1HTR2CPNMTASIC3HTR2A | |
| SCHEMBL3741829 | 0.74 | PKN2 (0.50) | PNMTLMNA | |
| SCHEMBL8638940 | 0.74 | NISCH (0.43) | SIGMAR1HTR2CHTR2AHTR2BHTR7 | |
| SCHEMBL8355638 | 0.74 | ASIC3 (0.46) | HTR2CASIC3HTR2AHTR2B | |
| SCHEMBL315185 | 0.73 | LMNA (0.50) | SIGMAR1HTR2CLMNARECQL | |
| SCHEMBL8323150 | 0.71 | ASIC3 (0.78) | HTR2CPNMTASIC3HTR2AHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104114543-A | Therapeutically active compounds and methods of use thereof | AGIOS PHARMACEUTICALS INC | 2014-10-22 | — | — | CN | claimed |
| CN-104114543-A | Therapeutically active compounds and methods of use thereof | AGIOS PHARMACEUTICALS INC | 2014-10-22 | — | — | CN | disclosed |
| US-5824690-A | TREATING ASTHMA, COUGH | HOECHST MARION ROUSSEL INC. (US) | 1998-10-20 | — | — | US | disclosed |