SCHEMBL8638737

SCHEMBL8638737

Fc1ccc(Oc2ccc(OCC=C(Br)Br)c(Cl)c2)c(F)c1

nearest known ligand 0.43

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
HTR2A P28223 6/20 0.43
SLC6A4 P31645 6/20 0.43
KCNH2 Q12809 5/20 0.43
PPARA Q07869 9/20 0.39
PPARG P37231 3/20 0.39
HSPB1 P04792 1/20 0.39
PPARD Q03181 6/20 0.39
AR P10275 1/20 0.38
KDR P35968 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8632796 0.80 TDP1 (0.41) HTR2ASLC6A4PPARAPPARGPPARD
SCHEMBL8633165 0.79 TDP1 (0.37) HTR2ASLC6A4PPARAPPARGPPARD
SCHEMBL8632925 0.79 FFAR1 (0.50) HTR2ASLC6A4KCNH2PPARAPPARD
SCHEMBL8959114 0.78 HTR2A (0.47) HTR2ASLC6A4KCNH2PPARAPPARG
SCHEMBL8632883 0.77 PPARD (0.39) HTR2ASLC6A4KCNH2PPARAPPARG
SCHEMBL8635559 0.76 PPARA (0.50) HTR2ASLC6A4KCNH2PPARAPPARG
SCHEMBL8632023 0.76 PPARD (0.40) HTR2ASLC6A4KCNH2PPARAPPARD
SCHEMBL8632019 0.73 FFAR4 (0.47) PPARAPPARGPPARD
SCHEMBL8633759 0.73 PNLIP (0.38) HTR2ASLC6A4KCNH2
SCHEMBL8638216 0.73 PPARA (0.41) PPARAPPARGPPARD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0648729-B1 Dihalopropene compound, insecticide/acaricide containing said dihalopropene compound as active ingredient and intermediate compound for use in production of said dihalopropene compound SUMITOMO CHEMICAL CO (JP) 1998-07-15 EP disclosed
US-5698702-A INTERMEDIATES FOR INSECTICIDES, ACARICIDES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1997-12-16 US disclosed
US-5530015-A Dihaloprene compound, insecticide/acaricide containing said dihalopropene compound as active ingredient, and intermediate compound for use in production of said dihalopropene compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1996-06-25 US disclosed
EP-0648729-A1 Dihalopropene compound, insecticide/acaricide containing said dihalopropene compound as active ingredient and intermediate compound for use in production of said dihalopropene compound SUMITOMO CHEMICAL COMPANY LIMITED (JP) 1995-04-19 EP disclosed