SCHEMBL8648602

SCHEMBL8648602

COC(=O)c1cc[c]c2ccccc12

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NR4A2 P43354 4/20 0.46
CREBBP Q92793 1/20 0.46
TSHR P16473 2/20 0.46
LMNA P02545 2/20 0.46
KDM4E B2RXH2 7/20 0.45
ALDH1A1 P00352 4/20 0.44
CFTR P13569 1/20 0.44
HSD17B10 Q99714 1/20 0.44
BRD4 O60885 2/20 0.44
POLB P06746 1/20 0.43
ATM Q13315 1/20 0.43
KMT2A Q03164 2/20 0.43
MEN1 O00255 1/20 0.43
MAP2K1 Q02750 1/20 0.43
HPGD P15428 1/20 0.43
NPSR1 Q6W5P4 1/20 0.43
CA1 P00915 1/20 0.40
CA2 P00918 1/20 0.40
CA5A P35218 1/20 0.40
CA9 Q16790 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8316214 0.88 LMNA (0.44) NR4A2CREBBPTSHRLMNAKDM4E
SCHEMBL8748348 0.82 TSHR (0.56) TSHRKDM4EALDH1A1HSD17B10HPGD
SCHEMBL4319548 0.80 KDM4E (0.42) CREBBPTSHRLMNAKDM4EALDH1A1
SCHEMBL249780 0.78 NR4A1 (0.48) NR4A2TSHRKDM4EALDH1A1HSD17B10
SCHEMBL29434198 0.77 BRD4 (0.59) NR4A2CREBBPTSHRLMNAKDM4E
SCHEMBL70381 0.77 BRD4 (0.59) NR4A2CREBBPTSHRLMNAKDM4E
SCHEMBL249202 0.77 ATM (0.47) TSHRKDM4EALDH1A1HSD17B10POLB
SCHEMBL9115108 0.76 ALDH1A1 (0.54) TSHRLMNAALDH1A1POLBKMT2A
SCHEMBL5213229 0.74 AKR1C3 (0.46) LMNAKDM4EALDH1A1HSD17B10POLB
SCHEMBL20591914 0.73 HSD17B10 (0.46) TSHRLMNAKDM4EALDH1A1HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12018122-B2 Method for producing silane-modified polymers MERZ+BENTELI AG (CH) 2024-06-25 US disclosed
EP-3877438-B1 METHOD FOR THE PREPARATION OF SILANE-MODIFIED POLYMERS MERZ BENTELI AG (CH) 2023-06-14 EP disclosed
CN-113166358-B Process for preparing silane-modified polymers 默兹奔特利股份公司 2023-03-28 CN disclosed
US-20210395450-A1 METHOD FOR PRODUCING SILANE-MODIFIED POLYMERS MERZ+BENTELI AG (CH) 2021-12-23 US disclosed
EP-3877438-A1 METHOD FOR PRODUCING SILANE-MODIFIED POLYMERS merz+benteli ag (CH) 2021-09-15 EP disclosed
CN-113166358-A Process for preparing silane-modified polymers 默兹奔特利股份公司 2021-07-23 CN disclosed
EP-2952096-B1 Amide compound, an arthropod pest control agent and a method for controlling arthropod pest SUMITOMO CHEMICAL CO (JP) 2018-04-04 EP disclosed
US-9814235-B2 Method for controlling arthropod pest SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2017-11-14 US disclosed
CN-104955332-B The method of preventing and treating arthropod insect 住友化学株式会社 2017-03-29 CN disclosed
EP-2952096-A1 METHOD FOR CONTROLLING ARTHROPOD PEST Sumitomo Chemical Company, Limited (JP) 2015-12-09 EP disclosed
US-20150344466-A1 METHOD FOR CONTROLLING ARTHROPOD PEST SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2015-12-03 US disclosed
CN-104955332-A Method for controlling arthropod pest SUMITOMO CHEMICAL CO 2015-09-30 CN disclosed
US-20150005348-A1 AMIDE COMPOUND AND USE THEREOF FOR PEST CONTROL SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2015-01-01 US disclosed
EP-2813492-A1 AMIDE COMPOUND AND USE THEREOF FOR PEST CONTROL Sumitomo Chemical Co., Ltd (JP) 2014-12-17 EP disclosed
CN-104105694-A Amide compound and use thereof for pest control SUMITOMO CHEMICAL CO 2014-10-15 CN disclosed
EP-0866367-A2 Radiation sensitive composition JSR Corporation (JP) 1998-09-23 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150344466-A1 METHOD FOR CONTROLLING ARTHROPOD PEST H1-0, H1-3, H1-2 NR4A2 870/4885CREBBP 3551/4885TSHR 507/4885
US-20150005348-A1 AMIDE COMPOUND AND USE THEREOF FOR PEST CONTROL RPS8, MT-CO2, ARG1 NR4A2 677/4885CREBBP 4026/4885TSHR 235/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.