SCHEMBL8652149

SCHEMBL8652149

OCCOc1ccc(-c2nc(O)nc(-c3ccc(Br)cc3)n2)cc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 2/20 0.48
KMT2A Q03164 2/20 0.48
KDM4E B2RXH2 2/20 0.48
MAPT P10636 2/20 0.48
L3MBTL1 Q9Y468 1/20 0.46
DHPS P49366 1/20 0.43
NR1I2 O75469 1/20 0.42
ALDH1A1 P00352 2/20 0.42
RECQL P46063 1/20 0.42
CYP1B1 Q16678 2/20 0.41
GAA P10253 1/20 0.41
CYP1A2 P05177 1/20 0.40
GPR119 Q8TDV5 1/20 0.40
S1PR1 P21453 1/20 0.39
LSS P48449 1/20 0.39
SMPD1 P17405 1/20 0.39
CYP19A1 P11511 1/20 0.39
LMNA P02545 2/20 0.39
TP53 P04637 2/20 0.39
MAPK1 P28482 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8918234 0.86 ALDH1A1 (0.56) MEN1KMT2AKDM4EMAPTL3MBTL1
SCHEMBL8651033 0.84 MAPT (0.48) MEN1KMT2AMAPTL3MBTL1DHPS
SCHEMBL29356875 0.82 MEN1 (0.47) MEN1KMT2AKDM4EMAPTL3MBTL1
SCHEMBL580702 0.82 MEN1 (0.47) MEN1KMT2AKDM4EMAPTL3MBTL1
SCHEMBL14004242 0.81 ALDH1A1 (0.56) MEN1KMT2AKDM4EMAPTL3MBTL1
SCHEMBL663667 0.81 ALDH1A1 (0.60) KDM4EL3MBTL1NR1I2ALDH1A1RECQL
SCHEMBL8380964 0.80 DHPS (0.48) DHPSCYP1B1TP53MAPK1
SCHEMBL16500062 0.78 ALDH1A1 (0.64) MEN1KMT2AKDM4EMAPTL3MBTL1
SCHEMBL4687161 0.78 ALOX15 (0.52) KDM4ENR1I2ALDH1A1RECQLGAA
SCHEMBL8380968 0.76 MEN1 (0.45) MEN1KMT2AKDM4EMAPTL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5726309-A ULTRAVIOLET RADIATION ABSORBERS; THERMAL STABILIZERS FOR POLYMER SUBSTRATES, ESPECIALLY AUTOMOTIVE COATINGS CIBA SPECIALTY CHEMICALS CORPORATION (US) 1998-03-10 US disclosed
US-5684070-A FILM WITH TRIAZINE RESORCINOL COMPOUND STABILIZERS FOR RADIATION RESISTANCE CIBA SPECIALTY CHEMICALS CORPORATION (US) 1997-11-04 US disclosed
US-5681955-A PHOTOSTABILITY OF POLYMERS CIBA SPECIALTY CHEMICALS CORPORATION (US) 1997-10-28 US disclosed
US-5679794-A ACTINIC LIGHT RESISTANCE, PROCESSING HEAT RESISTANCE CIBA-GEIGY CORPORATION (US) 1997-10-21 US disclosed
US-5675004-A POLYMER STABILIZERS TO PROTECT AGAINST ACTINIC RADIATION COVERING MORE OF THE NEAR-UV SPECTRUM; DISCOLORATION INHIBITION; SYNERGISTIC EFFECT WITH HINDERED AMINES; ALKYD, ACRYLIC, URETHANE COATINGS CIBA-GEIGY CORPORATION (US) 1997-10-07 US disclosed
US-5512621-A STABILIZER FOR POLYOLEFINS CIBA-GEIGY CORPORATION (US) 1996-04-30 US disclosed