SCHEMBL8658196

SCHEMBL8658196

O=C(Nc1ccccc1)Nc1ccc(S(=O)(=O)NC(=O)c2ccc3ccccc3c2)cc1

nearest known ligand 0.71

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
GPR27 Q9NS67 1/20 0.71
NPC1 O15118 2/20 0.58
MAPT P10636 2/20 0.58
RAB9A P51151 2/20 0.58
CA2 P00918 2/20 0.56
ENPP3 O14638 2/20 0.56
ENPP1 P22413 2/20 0.56
ENPP2 Q13822 2/20 0.56
PTPN1 P18031 1/20 0.54
DEGS1 O15121 1/20 0.53
POLB P06746 1/20 0.53
LMNA P02545 2/20 0.52
PLAU P00749 2/20 0.52
NR1H4 Q96RI1 1/20 0.51
CASP3 P42574 1/20 0.50
SENP7 Q9BQF6 1/20 0.50
CA12 O43570 1/20 0.50
CA1 P00915 1/20 0.50
CA9 Q16790 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7776124 0.91 ENPP2 (0.64) GPR27NPC1RAB9ACA2ENPP3
SCHEMBL7777619 0.90 GPR27 (0.68) GPR27NPC1MAPTRAB9AENPP3
SCHEMBL8766875 0.90 NPC1 (0.62) GPR27NPC1MAPTRAB9ACA2
SCHEMBL8664097 0.90 GPR27 (0.58) GPR27NPC1MAPTRAB9ACA2
SCHEMBL8767401 0.86 KAT6A (0.60) GPR27NPC1MAPTRAB9ACA2
SCHEMBL9179926 0.86 PTPN1 (0.67) GPR27ENPP3ENPP1ENPP2PTPN1
SCHEMBL8768061 0.85 RAB9A (0.64) GPR27NPC1MAPTRAB9ACA2
SCHEMBL6295620 0.85 MEN1 (0.65) NPC1RAB9ACA2LMNACA12
SCHEMBL6295675 0.85 SIRT1 (0.60) NPC1MAPTRAB9ACA2POLB
SCHEMBL9468048 0.84 LMNA (0.58) GPR27NPC1MAPTRAB9ALMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0699662-B1 Novel urea (thiourea) derivative and thermal recording sheet using same JUJO PAPER CO LTD (JP) 1998-10-21 EP disclosed
US-5661100-A HAVING HIGH SENSITIVITY, SUPERIOR THERMAL RESISTANCE, WATER RESISTANCE, OIL RESISTANCE NIPPON PAPER INDUSTRIES CO., LTD. (JP) 1997-08-26 US disclosed
EP-0699662-A1 Novel urea (thiourea) derivative and thermal recording sheet using same NIPPON PAPER INDUSTRIES CO., LTD. (JP) 1996-03-06 EP disclosed