Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.36 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.36 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PREP | P48147 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8660417 | 0.92 | POLB (0.43) | POLBALDH1A1NPSR1TP53MEN1 | |
| SCHEMBL12248426 | 0.87 | POLB (0.46) | POLBALDH1A1NPSR1TP53MEN1 | |
| SCHEMBL6858148 | 0.87 | ITGA4 (0.39) | TP53MEN1KMT2AKDM4ELMNA | |
| SCHEMBL8660375 | 0.85 | SLC6A1 (0.36) | POLBMEN1KMT2A | |
| SCHEMBL8662709 | 0.84 | MTNR1B (0.37) | POLBTP53MEN1KMT2ATSHR | |
| SCHEMBL8662093 | 0.84 | PIK3CD (0.35) | POLBMEN1KMT2AHPGD | |
| SCHEMBL8661014 | 0.81 | MAPT (0.38) | POLBMEN1KMT2ALMNAMAPT | |
| SCHEMBL8662962 | 0.80 | PIK3CD (0.47) | ALDH1A1NPSR1MEN1KMT2ACYP3A4 | |
| SCHEMBL8661342 | 0.80 | ALDH1A1 (0.35) | POLBALDH1A1MEN1KMT2ACYP3A4 | |
| SCHEMBL8662809 | 0.80 | CYP2D6 (0.37) | ALDH1A1TP53MEN1KMT2APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5714606-A | OLIGONUCLEOTIDE HAVING RECEPTOR BINDING SITES; ENZYME INHIBITORS, ANTIINFLAMMATORY AGENTS, MEDICAL DIAGNOSIS | ISIS PHARMACEUTICALS, INC. (US) | 1998-02-03 | — | — | US | disclosed |