SCHEMBL8662172

SCHEMBL8662172

COc1ccc(S(=O)(=O)N(C(N)=S)c2ccc(Cc3ccc(N(C(N)=S)S(=O)(=O)c4ccc(OC)cc4)cc3)cc2)cc1

nearest known ligand 0.51

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
TP53 P04637 7/20 0.51
LMNA P02545 2/20 0.51
ALDH1A1 P00352 4/20 0.49
USP2 O75604 1/20 0.49
MAPT P10636 5/20 0.48
CYP1A2 P05177 1/20 0.48
CYP3A4 P08684 1/20 0.48
GAA P10253 1/20 0.48
CYP2C9 P11712 1/20 0.48
CYP2C19 P33261 1/20 0.48
KEAP1 Q14145 1/20 0.48
NFE2L2 Q16236 1/20 0.48
THRB P10828 2/20 0.46
F2 P00734 2/20 0.46
HPGD P15428 2/20 0.46
KMT2A Q03164 2/20 0.46
HSP90AA1 P07900 2/20 0.46
TAS2R14 Q9NYV8 1/20 0.45
POLB P06746 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8620628 0.88 TP53 (0.55) TP53LMNAALDH1A1USP2MAPT
SCHEMBL6466028 0.87 KMT2A (0.47) TP53LMNAALDH1A1MAPTCYP1A2
SCHEMBL8625094 0.85 LMNA (0.49) TP53LMNAMAPTCYP1A2CYP3A4
SCHEMBL8837732 0.75 ALDH1A1 (0.39) LMNAALDH1A1CYP3A4GAAHPGD
SCHEMBL6466488 0.75 SAE1 (0.44) TP53LMNAALDH1A1MAPTCYP1A2
SCHEMBL9478142 0.74 TP53 (0.73) TP53LMNAALDH1A1USP2MAPT
SCHEMBL6462883 0.73 PTGES (0.52) LMNA
SCHEMBL27679 0.72 LMNA (0.54) TP53LMNAALDH1A1MAPTCYP1A2
SCHEMBL10372895 0.72 LTA4H (0.55) ALDH1A1GAATAS2R14
SCHEMBL6466688 0.71 LMNA (0.43) TP53LMNAALDH1A1MAPTCYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0792755-B1 Thermosensitive recording material OJI PAPER CO (JP) 1998-11-11 EP disclosed
EP-0792755-A1 Thermosensitive recording material OJI PAPER COMPANY LIMITED (JP) 1997-09-03 EP disclosed
US-5612280-A AROMATIC SULFONYLUREA AND SULFONYLTHIOUREA DERIVATIVES AS COLOR DEVELOPERS; COLORFASTNESS, STORAGE STABILITY, WHITENESS NEW OJI PAPER CO., LTD. (JP) 1997-03-18 US disclosed
EP-0604832-A2 Thermosensitive recording material NEW OJI PAPER CO., LTD. (JP) 1994-07-06 EP disclosed