Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A1 | P30531 | 4/20 | 0.33 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.31 |
| ▸ | SLC6A11 | P48066 | 1/20 | 0.31 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.31 |
| ▸ | RBP4 | P02753 | 1/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
| ▸ | NAMPT | P43490 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.30 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.30 |
| ▸ | ITGAL | P20701 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8661002 | 0.84 | TP53 (0.33) | SLC6A1SLC6A11HTT | |
| SCHEMBL6858148 | 0.84 | ITGA4 (0.39) | ITGA4RBP4 | |
| SCHEMBL8660375 | 0.83 | SLC6A1 (0.36) | SLC6A1SLC6A11RIPK1RBP4HTT | |
| SCHEMBL8662709 | 0.82 | MTNR1B (0.37) | SLC6A1ITGA4SLC6A11RIPK1RBP4 | |
| SCHEMBL8662093 | 0.82 | PIK3CD (0.35) | SLC6A1SLC6A11RIPK1RBP4HTT | |
| SCHEMBL8662486 | 0.81 | MTNR1B (0.40) | — | |
| SCHEMBL8661410 | 0.79 | ITGA4 (0.42) | ITGA4 | |
| SCHEMBL8660382 | 0.79 | DRD2 (0.38) | ITGA4RIPK1RBP4EPHX2 | |
| SCHEMBL8660410 | 0.79 | POLB (0.44) | — | |
| SCHEMBL8661352 | 0.78 | KMT2A (0.40) | HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5714606-A | OLIGONUCLEOTIDE HAVING RECEPTOR BINDING SITES; ENZYME INHIBITORS, ANTIINFLAMMATORY AGENTS, MEDICAL DIAGNOSIS | ISIS PHARMACEUTICALS, INC. (US) | 1998-02-03 | — | — | US | disclosed |
| EP-0739335-A4 | PYRROLIDINE-CONTAINING MONOMERS AND OLIGOMERS | ISIS PHARMACEUTICALS INC (US) | 1997-04-02 | — | — | EP | disclosed |
| EP-0739335-A1 | PYRROLIDINE-CONTAINING MONOMERS AND OLIGOMERS | ISIS PHARMACEUTICALS, INC. (US) | 1996-10-30 | — | — | EP | disclosed |
| WO-1995018792-A1 | PYRROLIDINE-CONTAINING MONOMERS AND OLIGOMERS | ISIS PHARMACEUTICALS, INC. (US) | 1995-07-13 | — | — | WO | disclosed |