SCHEMBL8664709

SCHEMBL8664709

CC(C)CCO[Si](OCCC(C)C)(c1ccccc1)c1ccccc1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TLR8 Q9NR97 1/20 0.37
HTT P42858 1/20 0.37
ALDH1A1 P00352 2/20 0.36
PPARG P37231 1/20 0.36
KDM4E B2RXH2 1/20 0.36
HSD17B10 Q99714 1/20 0.36
TDP1 Q9NUW8 1/20 0.36
MAPK1 P28482 1/20 0.36
IDO1 P14902 1/20 0.36
GABRP O00591 1/20 0.35
GABRD O14764 1/20 0.35
GABRA1 P14867 1/20 0.35
GABRB1 P18505 1/20 0.35
GABRG2 P18507 1/20 0.35
GABRB3 P28472 1/20 0.35
GABRA5 P31644 1/20 0.35
GABRA3 P34903 1/20 0.35
GABRA2 P47869 1/20 0.35
GABRB2 P47870 1/20 0.35
GABRA4 P48169 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9135130 0.84 DUT (0.40) TLR8HTTALDH1A1PPARGKDM4E
SCHEMBL8669439 0.84 TLR8 (0.37) TLR8HTTALDH1A1PPARGKDM4E
SCHEMBL1314561 0.82 TLR8 (0.36) TLR8HTTALDH1A1PPARGKDM4E
SCHEMBL17375324 0.82 SMYD2 (0.41) TLR8HTTALDH1A1PPARGKDM4E
SCHEMBL1313464 0.81 TLR8 (0.39) TLR8HTTALDH1A1PPARGKDM4E
SCHEMBL655583 0.79 ALDH1A1 (0.38) TLR8ALDH1A1HPGD
SCHEMBL27835013 0.78 GABRP (0.35) TLR8HTTALDH1A1PPARGKDM4E
SCHEMBL106121 0.77 LMNA (0.39) TLR8HTTALDH1A1KDM4EHPGD
SCHEMBL706124 0.75 LMNA (0.38) TLR8HTTALDH1A1HPGDESR1
SCHEMBL5363348 0.75 CA2 (0.41) ALDH1A1TDP1MAPK1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2584005-B1 TYPICAL METAL CONTAINING POLYSILOXANE COMPOSITION, PROCESS FOR PRODUCTION OF SAME, AND USES THEREOF TOSOH CORP (JP) 2018-02-21 EP disclosed
EP-2584005-A1 TYPICAL METAL CONTAINING POLYSILOXANE COMPOSITION, PROCESS FOR PRODUCTION OF SAME, AND USES THEREOF Tosoh Corporation (JP) 2013-04-24 EP disclosed
EP-0530814-B1 Method for producing a stereospecific polyolefin TOSOH CORP (JP) 1998-12-16 EP disclosed
EP-0474157-B1 Method for producing a stereospecific polyolefin TOSOH CORP (JP) 1996-12-04 EP disclosed
EP-0475134-B1 Method for producing a stereospecific polyolefin TOSOH CORP (JP) 1996-11-06 EP disclosed
EP-0504744-B1 Method for producing a stereospecific polyolefin TOSOH CORP (JP) 1996-07-17 EP disclosed
US-5489634-A EFFICIENT SELECTIVE CATALYTIC POLYMERIZATION OF ALPHA-OLEFINS YIELDS HIGH MOLECULAR WEIGHT SPHERICAL PARTICLES HAVING HIGH BULK DENSITY, CONTROLLED PARTICLE SIZE AND MOLECULAR WEIGHT DISTRIBUTION TOSOH CORPORATION (JP) 1996-02-06 US disclosed
US-5481056-A Process for the preparation of polyolefins TOSOH CORPORATION (JP) 1996-01-02 US disclosed
US-5468810-A Process for producing a propylene block copolymer UBE INDUSTRIES, LTD. (JP) 1995-11-21 US disclosed
EP-0376145-B1 Method for producing a stereoregular polyolefin TOSOH CORP (JP) 1994-03-23 EP disclosed
EP-0275317-B1 PROCESS FOR PRODUCING STEREOREGULAR POLYOLEFINS TOSOH CORPORATION (JP) 1990-11-28 EP disclosed
EP-0376145-A2 Method for producing a stereoregular polyolefin Tosoh Corporation (JP) 1990-07-04 EP disclosed
EP-0275317-A1 PROCESS FOR PRODUCING STEREOREGULAR POLYOLEFINS TOSOH CORPORATION (JP) 1988-07-27 EP disclosed
EP-0095855-B1 PROCESS FOR POLYMERIZING ETHYLENE UBE INDUSTRIES, LTD. (JP) 1987-04-08 EP disclosed
US-4435550-A GRIGNARD REAGENT, ALUMINUM HALIDE, ORGANOSILANE, TITANIUM HALIDE, ESTER, TRIALKYLALUMINUM UBE INDUSTRIES, LTD. (JP) 1984-03-06 US disclosed
US-4420594-A USING AS CATALYST A REACTION PRODUCT OF AN ALUMINUM HALIDE WITH AN ORGANIC SILICON COMPOUND FOLLOWED BY REACTION WITH A GRIGNARD COMPOUND AND TITANIUM TETRAHALIDE UBE INDUSTRIES, LTD. (JP) 1983-12-13 US disclosed
EP-0095855-A1 Process for polymerizing ethylene UBE INDUSTRIES, LTD. (JP) 1983-12-07 EP disclosed
EP-0074276-A1 Process for polymerization of ethylene UBE INDUSTRIES, LTD. (JP) 1983-03-16 EP disclosed
EP-0074275-A1 Process for polymerization of alpha-olefins UBE INDUSTRIES, LTD. (JP) 1983-03-16 EP disclosed
US-4365048-A COORDINATION CATALYST, ALUMINUM COCATALYST, ESTER UBE INDUSTRIES, LTD. (JP) 1982-12-21 US disclosed