Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT3 | P40763 | 5/20 | 1.00 |
| ▸ | MAOA | P21397 | 4/20 | 0.56 |
| ▸ | MAPT | P10636 | 6/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.50 |
| ▸ | TSHR | P16473 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | MAOB | P27338 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | TTR | P02766 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 6/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | RECQL | P46063 | 4/20 | 0.47 |
| ▸ | ELANE | P08246 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2801404 | 1.00 | STAT3 (1.00) | STAT3MAOAMAPTALDH1A1TDP1 | |
| SCHEMBL10037431 | 1.00 | STAT3 (1.00) | STAT3MAOAMAPTALDH1A1TDP1 | |
| SCHEMBL13843896 | 0.91 | STAT3 (0.84) | STAT3MAOAMAPTALDH1A1TDP1 | |
| SCHEMBL10037441 | 0.90 | STAT3 (0.81) | STAT3MAOAMAPTALDH1A1TDP1 | |
| SCHEMBL10037444 | 0.89 | STAT3 (0.80) | STAT3MAOAMAPTALDH1A1TDP1 | |
| SCHEMBL22325634 | 0.89 | STAT3 (0.80) | STAT3MAOAMAPTALDH1A1TDP1 | |
| SCHEMBL22325626 | 0.89 | STAT3 (0.80) | STAT3MAOAMAPTALDH1A1TDP1 | |
| SCHEMBL22325628 | 0.89 | STAT3 (0.80) | STAT3MAOAMAPTALDH1A1TDP1 | |
| SCHEMBL22325644 | 0.88 | STAT3 (0.79) | STAT3MAOAMAPTALDH1A1TDP1 | |
| SCHEMBL10037443 | 0.87 | STAT3 (0.78) | STAT3MAOAMAPTALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 57 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1860103-B1 | ANTICANCER COMPOUND, INTERMEDIATE THEREFOR, AND PROCESSES FOR PRODUCING THESE | TAHEEBO JAPAN CO LTD (JP) | 2012-05-16 | — | — | EP | claimed |
| US-7910752-B2 | Anticancer compound, intermediate therefor, and processes for producing these | TAHEEBO JAPAN CO., LTD. (JP) | 2011-03-22 | — | — | US | claimed |
| US-20100215625-A1 | EFFICIENT PREPARATION OF NAPHTHOQUINONE ANTICANCER ACTIVE INGREDIENTS | TAHEEBO JAPAN CO., LTD. (JP) | 2010-08-26 | — | — | US | claimed |
| US-20090042977-A1 | Anticancer Compound, Intermediate Therefor, and Processes for Producing These | TAHEEBO JAPAN CO., LTD. (JP) | 2009-02-12 | — | — | US | claimed |
| EP-1860103-A1 | ANTICANCER COMPOUND, INTERMEDIATE THEREFOR, AND PROCESSES FOR PRODUCING THESE | Taheebo Japan Co., Ltd. (JP) | 2007-11-28 | — | — | EP | claimed |
| US-5663197-A | ANTITUMOR AND ANTICARCINOGENIC AGENTS | TAHEEBO JAPAN CO., LTD. (JP) | 1997-09-02 | — | — | US | claimed |
| WO-1994006786-A1 | 2-(1-HYDROXYETHYL)-5-HYDROXYNAPHTO[2,3-b]FURAN-4,9-DIONE AND ANTITUMOR AGENTS COMPRISING THIS COMPOUND | TAHEEBO JAPAN CO., LTD. (JP) | 1994-03-31 | — | — | WO | claimed |
| US-10919872-B2 | Method for producing 2-alkylcarbonylnaphtho[2,3-b]furan-4,9-dione-related substance, and said related substance | SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) | 2021-02-16 | — | — | US | disclosed |
| WO-2020161959-A1 | NAPHTHOQUINONE COMPOUND HAVING ANTIBACTERIAL AND ANTIVIRAL ACTIVITIES AND PHARMACEUTICAL USE THEREOF | タヒボジャパン株式会社 | 2020-08-13 | — | — | WO | disclosed |
| WO-2020161959-A1 | NAPHTHOQUINONE COMPOUND HAVING ANTIBACTERIAL AND ANTIVIRAL ACTIVITIES AND PHARMACEUTICAL USE THEREOF | タヒボジャパン株式会社 | 2020-08-13 | — | — | WO | disclosed |
| US-10738023-B2 | Method for producing 2-alkylcarbonylnaphtho[2,3-b]furan-4,9-dione-related substance, and said related substance | SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) | 2020-08-11 | — | — | US | disclosed |
| US-20200239424-A1 | METHOD FOR PRODUCING 2-ALKYLCARBONYLNAPHTHO[2,3-b]FURAN-4,9-DIONE-RELATED SUBSTANCE, AND SAID RELATED SUBSTANCE | SUMITOMO DAINIPPON PHARMA CO., LTD. (JP) | 2020-07-30 | — | — | US | disclosed |
| EP-2436669-B1 | Preparation of anticancer-active tricyclic compounds via alkyne coupling reaction | TAHEEBO JAPAN CO LTD (JP) | 2016-01-13 | — | — | EP | disclosed |
| CN-1144586-C | 2-(1-hydroxyethyl)-5-hydroxynaphtho{2,3-B}furan-4, 9-dione and antitumor agents comprising this compound | 太日保日本株式会社 | 2004-04-07 | — | — | CN | disclosed |
| US-5663197-A | ANTITUMOR AND ANTICARCINOGENIC AGENTS | TAHEEBO JAPAN CO., LTD. (JP) | 1997-09-02 | — | — | US | disclosed |
| US-5663197-A | ANTITUMOR AND ANTICARCINOGENIC AGENTS | TAHEEBO JAPAN CO., LTD. (JP) | 1997-09-02 | — | — | US | disclosed |
| US-5663197-A | ANTITUMOR AND ANTICARCINOGENIC AGENTS | TAHEEBO JAPAN CO., LTD. (JP) | 1997-09-02 | — | — | US | disclosed |
| WO-1994006786-A1 | 2-(1-HYDROXYETHYL)-5-HYDROXYNAPHTO[2,3-b]FURAN-4,9-DIONE AND ANTITUMOR AGENTS COMPRISING THIS COMPOUND | TAHEEBO JAPAN CO., LTD. (JP) | 1994-03-31 | — | — | WO | disclosed |
| WO-1994006786-A1 | 2-(1-HYDROXYETHYL)-5-HYDROXYNAPHTO[2,3-b]FURAN-4,9-DIONE AND ANTITUMOR AGENTS COMPRISING THIS COMPOUND | TAHEEBO JAPAN CO., LTD. (JP) | 1994-03-31 | — | — | WO | disclosed |
| WO-1994006786-A1 | 2-(1-HYDROXYETHYL)-5-HYDROXYNAPHTO[2,3-b]FURAN-4,9-DIONE AND ANTITUMOR AGENTS COMPRISING THIS COMPOUND | TAHEEBO JAPAN CO., LTD. (JP) | 1994-03-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10738023-B2 | Method for producing 2-alkylcarbonylnaphtho[2,3-b]furan-4,9-dione-related substance, and said related substance | ADH1C, ADH5, ADH1A | STAT3 4383/4885MAOA 341/4885MAPT 4210/4885 |
| US-20100215625-A1 | EFFICIENT PREPARATION OF NAPHTHOQUINONE ANTICANCER ACTIVE INGREDIENTS | NDUFB10, NQO2, NDUFA10 | STAT3 3608/4885MAOA 2250/4885MAPT 4484/4885 |
| US-20090042977-A1 | Anticancer Compound, Intermediate Therefor, and Processes for Producing These | NQO1, HADH, HADHB | STAT3 2252/4885MAOA 1750/4885MAPT 3191/4885 |
| US-20200239424-A1 | METHOD FOR PRODUCING 2-ALKYLCARBONYLNAPHTHO[2,3-b]FURAN-4,9-DIONE-RELATED SUBSTANCE, AND SAID RELATED SUBSTANCE | ADH1C, ADH5, ADH1A | STAT3 4383/4885MAOA 341/4885MAPT 4210/4885 |
| US-10919872-B2 | Method for producing 2-alkylcarbonylnaphtho[2,3-b]furan-4,9-dione-related substance, and said related substance | ADH1C, ADH5, ADH1A | STAT3 4383/4885MAOA 341/4885MAPT 4210/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.