Known targets — ChEMBL curated mechanism
GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQ
The experimentally established mechanism targets of Methyprylon. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methyprylon SCHEMBL8665841 | 0.94 | — | — | |
| Methyprylon SCHEMBL8665659 | 0.92 | — | — | |
| Methyprylon SCHEMBL8667940 | 0.92 | CYP3A4 (0.33) | — | |
| Methyprylon SCHEMBL155838 | 0.83 | LMNA (0.40) | — | |
| Methyprylon SCHEMBL10792726 | 0.80 | LMNA (0.38) | — | |
| Methyprylon SCHEMBL7683591 | 0.79 | LMNA (0.34) | — | |
| Methyprylon SCHEMBL9014931 | 0.79 | LMNA (0.34) | — | |
| Methyprylon SCHEMBL6695974 | 0.76 | LMNA (0.34) | — | |
| Methyprylon SCHEMBL623597 | 0.75 | LMNA (0.32) | — | |
| Methyprylon SCHEMBL1326559 | 0.75 | LMNA (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0580435-B1 | Diester monomer, its polymer, water-containing soft contact lens, and processing solution for contact lens | NOF CORP (JP) | 1998-09-16 | — | — | EP | disclosed |
| US-5466853-A | Diester monomer, its polymer, water-containing soft contact lens, and processing solution for contact lens | NOF CORPORATION (JP) | 1995-11-14 | — | — | US | disclosed |
| EP-0580435-A1 | Diester monomer, its polymer, water-containing soft contact lens, and processing solution for contact lens | NOF CORPORATION (JP) | 1994-01-26 | — | — | EP | disclosed |