Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 5/20 | 0.39 |
| ▸ | CES2 | O00748 | 2/20 | 0.38 |
| ▸ | CES1 | P23141 | 2/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 6/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.37 |
| ▸ | DPP4 | P27487 | 2/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4889343 | 0.86 | HTR2A (0.39) | HRH1CES2CES1TRPA1HTR2A | |
| SCHEMBL22042211 | 0.85 | HRH1 (0.46) | HRH1CES2CES1TRPA1HTR2A | |
| SCHEMBL4892666 | 0.82 | CES2 (0.42) | HRH1CES2CES1TRPA1HTR2A | |
| SCHEMBL22042217 | 0.80 | HRH1 (0.44) | HRH1CES2CES1TRPA1HTR2A | |
| SCHEMBL4450297 | 0.78 | HRH1 (0.41) | HRH1CES2CES1TRPA1HTR2A | |
| SCHEMBL270397 | 0.77 | HRH1 (0.56) | HRH1HTR2ATAAR1 | |
| SCHEMBL525687 | 0.76 | TSHR (0.40) | HRH1CES2CES1TRPA1HTR2A | |
| SCHEMBL8037602 | 0.76 | TRPA1 (0.48) | HRH1CES2CES1TRPA1HTR2A | |
| SCHEMBL687847 | 0.76 | AOC3 (0.46) | HRH1CES2CES1TRPA1HTR2A | |
| SCHEMBL13265139 | 0.76 | AOC3 (0.46) | HRH1CES2CES1TRPA1HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120077844-A1 | USE OF PIPERIDINE DERIVATIVES AS DERMO-DECONTRACTING AGENTS | L'OREAL (FR) | 2012-03-29 | — | — | US | disclosed |
| US-20100048624-A1 | USE OF PIPERIDINE DERIVATIVES AS DERMO-DECONTRACTING AGENTS | L'OREAL (FR) | 2010-02-25 | — | — | US | disclosed |
| US-7629359-B2 | Use of piperidine derivatives as dermo-decontracting agents | L'OREAL (FR) | 2009-12-08 | — | — | US | disclosed |
| EP-1765281-B1 | USE OF PIPERIDINE DERIVATIVES AS DERMO-DECONTRACTING AGENTS | OREAL (FR) | 2008-08-27 | — | — | EP | disclosed |
| US-20080194590-A1 | 4-Piperazinylthieno [2,3-D] Pyrimidine Compounds as Platelet Aggregation Inhibitors | PFIZER INC | 2008-08-14 | — | — | US | disclosed |
| US-20070259915-A1 | Use of Piperidine Derivatives as Dermo-Decontracting Agents | L'OREAL (FR) | 2007-11-08 | — | — | US | disclosed |
| EP-1765281-A1 | USE OF PIPERIDINE DERIVATIVES AS DERMO-DECONTRACTING AGENTS | L'OREAL (FR) | 2007-03-28 | — | — | EP | disclosed |
| WO-2006003030-A1 | USE OF PIPERIDINE DERIVATIVES AS DERMO-DECONTRACTING AGENTS | L'OREAL (FR) | 2006-01-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120077844-A1 | USE OF PIPERIDINE DERIVATIVES AS DERMO-DECONTRACTING AGENTS | PLOD3, CUTA, DSTN | HRH1 1617/4885CES2 2768/4885CES1 4055/4885 |
| US-20070259915-A1 | Use of Piperidine Derivatives as Dermo-Decontracting Agents | CUTA, PLOD3, PLIN5 | HRH1 1541/4885CES2 2739/4885CES1 4071/4885 |
| US-20080194590-A1 | 4-Piperazinylthieno [2,3-D] Pyrimidine Compounds as Platelet Aggregation Inhibitors | PFKP, PF4, P2RY4 | HRH1 582/4885CES2 3286/4885CES1 2626/4885 |
| US-20100048624-A1 | USE OF PIPERIDINE DERIVATIVES AS DERMO-DECONTRACTING AGENTS | PLOD3, CUTA, DSTN | HRH1 1617/4885CES2 2768/4885CES1 4055/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.