Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 11/20 | 0.45 |
| ▸ | MMP9 | P14780 | 11/20 | 0.45 |
| ▸ | MMP13 | P45452 | 10/20 | 0.45 |
| ▸ | ADAM17 | P78536 | 6/20 | 0.45 |
| ▸ | MMP3 | P08254 | 4/20 | 0.43 |
| ▸ | MMP7 | P09237 | 2/20 | 0.43 |
| ▸ | MMP2 | P08253 | 3/20 | 0.42 |
| ▸ | MMP8 | P22894 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8675935 | 0.74 | MMP9 (0.41) | MMP1MMP9MMP13ADAM17MMP3 | |
| SCHEMBL7419400 | 0.73 | KCNA5 (0.48) | MMP1MMP9MMP13MMP3MMP7 | |
| SCHEMBL11453114 | 0.69 | ALDH1A1 (0.56) | GAACA1CA2ACHEALDH1A1 | |
| SCHEMBL209395 | 0.68 | KMT2A (0.59) | GAAALDH1A1KMT2A | |
| SCHEMBL7350978 | 0.68 | KCNA5 (0.54) | MMP1MMP9MMP13MMP3MMP2 | |
| SCHEMBL26381709 | 0.67 | PKM (0.53) | MMP1MMP9MMP13MMP3MMP2 | |
| SCHEMBL6560866 | 0.67 | HIF1A (0.56) | GAAALDH1A1KMT2A | |
| SCHEMBL1521953 | 0.67 | LTA4H (0.58) | MMP1MMP9ACHEALDH1A1 | |
| SCHEMBL5678202 | 0.67 | MMP1 (0.50) | MMP1MMP9MMP13ADAM17MMP3 | |
| SCHEMBL28329266 | 0.67 | CA1 (0.48) | MMP1MMP9MMP13ADAM17MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5770624-A | INHIBITORS OF TUMOR NECROSIS FACTOR ALPHA AND MATRIX DEGRADING METALLOPROTEINEASE ACTIVITY | NOVARTIS CORP. (US) | 1998-06-23 | — | — | US | disclosed |